A Phase 1 Study of LNCB74 in Advanced Solid Tumors

{ "Phase 1 Study of LNCB74 for Advanced Solid Tumors", "This study is testing a new treatment called LNCB74 for people with advanced solid tumors, including ovarian, breast, endometrial, biliary tract, and non-small cell lung cancers. LNCB74 is an antibody-drug conjugate (a type of targeted therapy that delivers a drug directly to cancer cells) that works through an immunotherapy mechanism. You would receive LNCB74 intravenously (into a vein) in cycles lasting 21 days. The main goals are to find out how safe LNCB74 is, what side effects it might cause, and to determine the best dose for future studies. This study is currently open to adults aged 18 and older with advanced solid tumors that cannot be removed by surgery or have spread.", "design": "This is an open-label, Phase 1 study, meaning both you and the study team will know you are receiving LNCB74. It aims to enroll 145 participants to find the safest and most effective dose.", "commitments": "You would receive LNCB74 intravenously in 21-day dosing cycles. The study will evaluate your safety and tolerability for up to 24 months.", "compensation": "Not stated in the trial record.", "follow_up": "Your safety and tolerability will be evaluated for up to 24 months after starting the study.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06774963

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

Recruiting
PHASE1Ages 18+InterventionalTreatment
NextCure, Inc.
~145 participants
Updated 2026-08-21 on ClinicalTrials.gov
What's tested:LNCB74

At a glance

Recruiting sites
12 of 14 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Evaluate the safety and tolerability of LNCB74
Measured over 24 months
+1 more outcome measured
Ovarian Cancer
Breast Cancer
Endometrial Cancer
Biliary Tract Cancer
Non-Small Cell Lung Cancer
Advanced or Metastatic Solid Tumors
14 sites across 11 states
Texas3
Pennsylvania2
California1
Kentucky1
Massachusetts1
Missouri1
New Jersey1
New York1

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  • Evaluate the safety and tolerability of LNCB7424 months

    Incidence of AEs, SAEs, AEs meeting protocol defined DLT criteria, AEs leading to discontinuation and death, and laboratory abnormalities per NCI CTCAE v5.0

  • Define a recommended Phase 2 dose (RP2D) of LNCB74Up to 24 months

    Maximum tolerated dose (MTD), maximum administered dose (MAD) and/or recommended Phase 2 dose (RP2D) of LNCB74