Stem Cell Therapy for Early Alzheimer's Disease

This study is looking at whether a stem cell treatment called adMSC can help people with early Alzheimer's disease or mild memory problems. adMSC uses your own stem cells, taken from a small fat sample, which are then processed and given back to you through an IV. Researchers want to see if this treatment can reduce inflammation in the brain, improve brain activity, and slow down the progression of Alzheimer's disease. To join, you need to be between 60 and 80 years old and have a diagnosis of late pre-symptomatic or mild cognitive impairment (MCI) due to Alzheimer's disease. The study is currently unclear on its recruitment status.

Study design
This is an open-label study, meaning both you and the study team will know what treatment you are receiving. It plans to enroll 12 participants.
What's involved
You will have a small fat biopsy, receive 4 infusions of stem cells over 12 weeks, and visit the clinic every 2-4 weeks for the first 4 months.
Compensation
Not stated in the trial record.
Follow-up
The study measures changes up to 169 days from the first infusion.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06775964

Stem Cell Therapy for Early Alzheimer's Disease

Recruiting
PHASE1Ages 60–80InterventionalTreatment
Paul E Schulz
~12 participants
Updated 2026-04-20 on ClinicalTrials.gov
What's tested:adMSC

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in TSPO levels, measured by the PET scan, from baseline to midpoint and baseline to end of study
Measured over Baseline, midpoint (169 days from 1st infusion)
+1 more outcome measured
Cognitive Dysfunction
1 sites across 1 states
Texas1
  • Paul E Schulz, MD · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston

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  • Change in TSPO levels, measured by the PET scan, from baseline to midpoint and baseline to end of studyBaseline, midpoint (169 days from 1st infusion)

    Level of TSPO PET tracer will be measured for each PET scan. TSPO positivity, which is a marker for activated microglia, correlates with neuroinflammation

  • Inflammatory cytokines in CSF following adMSC therapyBaseline, midpoint (169 days from 1st infusion)

    Inflammatory cytokine panel in CSF will be measured using commercially available immunosorbent assays to determine potential treatment effects. Aggregate values and percentages will be reported.