Endodontic Microsurgery with Platelet-Rich Fibrin
This study is looking into a dental procedure called endodontic microsurgery (also known as apicoectomy), which is used when a root canal treatment hasn't fully healed an infection around the tooth root. Researchers want to see if adding something called Platelet Rich Fibrin (PRF) to the surgery helps the bone heal better. PRF is a biological material that will be used to fill the area after the surgery. The study will compare how well teeth heal with and without PRF. You might be able to join if you are between 18 and 90 years old, have certain front or premolar teeth with a failed root canal and an infection, and meet other health criteria. The main way they will measure success is by looking at changes in bone healing over 6, 12, and 18 months.
- Study design
- This is an interventional study planning to enroll 20 participants, comparing endodontic microsurgery with and without Platelet Rich Fibrin.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 18 months to measure bone healing.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Endodontic Microsurgery
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Mark Schachman, DMD · PRINCIPAL_INVESTIGATOR
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in bone deposition using voxel-based imposition6 months, 12 months, and 18 months
From the CBCT images Invivo imaging software (Anatomage, San Jose, CA, USA) will be used to obtain measurements from voxel-based superimposition. The voxel-based imposition is automated by the software to match the voxel grayscale values from the two image volumes. Originally developed by Bazina et al. this analysis method has been demonstrated to show reliable and accurate data. The Linear measurements will be obtained on the cross-section view (sagittal, coronal, and axial) of the periapical lesion on CBCT-1 (6 months) and CBCT-2 (12 months) images.