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Registry for Genicular Artery Embolization for Knee Arthritis

This study is creating a registry to collect information on patients receiving genicular artery embolization (GAE) for knee osteoarthritis (KOA). GAE is a minimally invasive procedure that uses X-ray guidance to block small blood vessels in the knee, which is thought to reduce inflammation and pain. The goal is to see how effective GAE is over time in reducing knee pain, measured by the WOMAC score (a questionnaire about pain, stiffness, and function). You may be able to join if you are at least 18 years old, have knee pain from KOA for more than 6 months that hasn't improved with other treatments, and have specific grades of osteoarthritis on X-rays. This study is currently collecting data.

Study design
This is an observational study that plans to enroll up to 100 participants. It is a registry, meaning it collects information without directly testing a new intervention.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for at least one year after enrollment, with pain levels measured at that time.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06781463

Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis

Recruiting
Not specifiedAges 18+Observational
University of Chicago
~100 participants
Updated 2026-05-13 on ClinicalTrials.gov
What's tested:Registry (N/A)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
Measured over 1 year of enrollment/patient

Conditions

Knee Osteoarthritis
Knee Osteoarthritis (Knee OA)
Knee Osteoarthritis (OA)

Explore related trials

Osteoarthritis of knee

NCT06781463

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Chicago Duchossois Center for Advanced Medicine

    Chicago, Illinoisstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Tiana Jackson
[email protected]
773.795.7030
Email the study team

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Eligibility criteria

Inclusion

Patients aged \>=18
Bilateral or unilateral knee pain attributed to knee osteoarthritis (KOA). For bilateral KOA patients, the more severe knee will be permitted inclusion to the registry
Grade 1-3 Osteoarthritis as diagnosed on standing weight-bearing knee radiographs per the Kellen-Lawrence Grading scale
Knee pain \>6 months refractory to conservative medical management (Nonsteroidal anti-inflammatory drugs, acetaminophen, etc.)
Not eligible for surgical knee replacement or patient's personal preference to undergo Genicular Artery Embolization (GAE) for reasons such as minimally invasiveness of GAE

Exclusion

Active malignancy
Active infection of the affected knee
Platelets \<50,000/uL, INR \>2.0 (unless on anticoagulation that can be reversed or performing radial/pedal access without reversal)
Corticosteroid injection of the affected knee within 3 months of enrollment
Rheumatoid arthritis or other seronegative arthropathy
Previous surgery (excluding arthroscopy) of the affected knee
Grade 4 per Kellgren-Lawrence Grading Scale of the affected knee
Pregnancy or expected pregnancy
Glomerular Filtration Rate (GFR) \<30
Anaphylactic reaction to iodinated contrast
Moderate to severe pain in other lower limb joints
Body weight \>400 lbs. (prohibiting safe angiography)
Peripheral arterial disease of the treated extremity (Rutherford Grade 2 or greater)

What this trial measures

  • Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)1 year of enrollment/patient

    The investigators will describe differences in pain response with Genicular Artery Embolization (GAE) compared to a sham procedure when treating medically refractory mild to moderate Knee Osteoarthritis (KOA) at 12 months as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain subscale score. A higher score index a higher pain level while a lower score indicates lower pain levels. The score range is 0 to 100.