Physical Activity and Snacking in Youth with Prediabetes
This study is looking at how increasing physical activity and stopping evening snacking might improve the health of young people (ages 12-18) who have prediabetes. Prediabetes means your blood sugar levels are higher than normal but not yet high enough to be type 2 diabetes. Researchers believe that unhealthy eating habits, like evening snacking, and not enough exercise can contribute to prediabetes. Participants will be randomly assigned to either a group that aims for 10,000 steps daily and no snacking after 8 PM, or a standard care group. The main goal is to see if these changes improve how well the body uses insulin (insulin sensitivity) after 8 weeks. The study plans to enroll 80 participants and its current status is unclear.
- Study design
- This is an interventional study that will randomly assign 80 participants to one of two groups. It is not specified if the study is blinded or what phase it is in.
- What's involved
- Participants in the intervention group will be asked to walk at least 10,000 steps daily (5 or more days a week) and stop eating snacks after 8:00 p.m. for 8 weeks. Insulin sensitivity will be measured at week 9-10.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will have their insulin sensitivity measured 9-10 weeks after the 8-week intervention period.
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Effect of Increased Physical Activity and Stopping Evening Snacking in Metabolic Health in Youth With Prediabetes
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Mustafa Tosur, MD · PRINCIPAL_INVESTIGATOR · Baylor College of Medicine
Who to contact
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What this trial measures
- Insulin sensitivity index for glucose disposal (ISI [Gly]) during oral glucose tolerance testAt week 9-10 following completion of 8 weeks of intervention period
Insulin sensitivity index for glycemia (ISI \[Gly\]) will be calculated with a formula using insulin and glucose area under the curves during oral glucose tolerance tests (OGTT) as described previously (Belfiore et al., Metabolism, 2001): ISI (Gly) = 2 / \[INSp x GLYp) + 1\] INSp: insulinemic area during OGTT with 3 (0, 1h and 2h) or 5 sampling (0, 30, 60, 90 and 120 min) GLYp: glycemic area during OGTT (0, 1h and 2h) or 5 sampling (0, 30, 60, 90 and 120 min) INSp and GLYp are expressed by taking the mean normal value as 1, i.e., by dividing the value observed in the person under study by the mean normal value so that, if INSp (or GLYp) is 1.5-fold the mean normal values, it will be considered as equal to 1.5, and so on. We will use appropriate "mean normal values," which will be derived from data obtained in our laboratory.