This study is looking at differences in pain and hormone levels between women who have migraine, endometriosis, both conditions, or neither. Researchers will use devices to apply heat, cold, and pressure, and you'll rate your pain. They will also collect blood, saliva, or urine to check your sex hormone levels (like prolactin, testosterone, and estradiol). The main goal is to understand how your body's natural pain control (Conditioned Pain Modulation or CPM) and hormone levels differ among these groups. This study is open to women aged 12-45 who have been diagnosed with migraine, endometriosis, or both, as well as healthy women without chronic pain. The study is currently recruiting 120 participants.

Study design

This is an observational study involving 120 women. It is not a treatment study but aims to understand differences between groups.

What's involved

You will attend a single 2.5-3 hour study visit. During this visit, you will complete questionnaires and have experimental pain tests using thermal and pressure devices, and provide blood, saliva, or urine samples.

Compensation

Not stated in the trial record.

Follow-up

Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.