Investigating Ubamatamab for Platinum-Resistant Ovarian Cancer

This study is looking into a drug called ubamatamab for adults with advanced ovarian, fallopian tube, or primary peritoneal cancer that has grown despite previous platinum-based chemotherapy. Researchers want to understand how safe and effective ubamatamab is, both by itself and when combined with other anti-cancer drugs like bevacizumab, cemiplimab, fianlimab, and PLD (a type of chemotherapy). The main goal is to see if these treatments can shrink tumors. You might be able to join if you are at least 18 years old, a woman, and have measurable cancer that has progressed. The study aims to enroll 220 participants, but its current recruitment status is unclear.

Study design
This interventional study plans to enroll 220 participants. It is testing ubamatamab alone and in combination with other drugs.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The main treatment effect will be measured for up to 3 years.

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NCT06787612

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

Recruiting
PHASE2Ages 18+InterventionalTreatment
Regeneron Pharmaceuticals
~297 participants
Updated 2026-08-12 on ClinicalTrials.gov
What's tested:UbamatamabBevacizumabCemiplimabFianlimabPLDSarilumab

At a glance

Recruiting sites
55 of 55 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Objective Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 by investigator assessment
Measured over Up to 3 years
Ovarian Cancer
Fallopian Tube Cancer
Primary Peritoneal Cancer
55 sites across 29 states
South Korea7
Turkey (Türkiye)7
Taiwan6
Florida4
Quebec3
California2
Pennsylvania2
Wisconsin2
  • Clinical Trial Management · STUDY_DIRECTOR · Regeneron Pharmaceuticals

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  • Objective Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 by investigator assessmentUp to 3 years