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Optimizing Transcranial Magnetic Stimulation for Stimulant Use Disorder

This study is exploring ways to improve Transcranial Magnetic Stimulation (TMS) for people with Stimulant Use Disorder. TMS is a non-invasive procedure that uses magnetic fields to stimulate nerve cells in the brain. Researchers will test different ways of delivering TMS pulses to the brain: syncing them to the 'peak' or 'trough' of your brain's natural theta waves (closed-loop), or delivering them without syncing (open-loop). The goal is to see which method best changes brain activity (TEP individual response) and improves thinking skills (cognitive response). The study plans to enroll 50 adults who have Stimulant Use Disorder and are currently in treatment and abstinent for at least two weeks. Up to 10 healthy adults will also participate to help set up the study.

Study design
This interventional study plans to enroll 50 participants with Stimulant Use Disorder and up to 10 healthy controls. It is not specified if the study is randomized or blinded.
What's involved
You would have two lab visits, which include an MRI scan, EEG recordings, and TMS stimulation. The study measures brain activity at 2 hours and cognitive response immediately after a specific TMS treatment.
Compensation
Not stated in the trial record.
Follow-up
The primary outcomes are measured at 2 hours and immediately after a specific TMS treatment.

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NCT06790576

Optimizing Transcranial Magnetic Stimulation for Stimulant Use Disorder

Recruiting
PHASE1Ages 18+InterventionalTreatment
University of Minnesota
~50 participants
Updated 2026-02-09 on ClinicalTrials.gov
What's tested:closed-loop-peakOpen-loopclosed-loop-trough

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
TEP individual response
Measured over 2 hours
+1 more outcome measured

Conditions

Stimulant Use Disorder

Explore related trials

Healthy ControlStimulant use disorder

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Kelvin Lim · PRINCIPAL_INVESTIGATOR · University of Minnesota

Who to contact

Melnie Martie
[email protected]
612-301-2449
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age 18 or older
Ability to provide consent and comply with all study procedures.
Meets Diagnostic and Statistical Manual of Mental Disorders criteria for StUD (As assessed by MINI and self-report; Participants may have current comorbid drug use, but primary diagnosis must be StUD; does not apply to healthy control participants).
At least 2 weeks of abstinence from substance use (other than caffeine or nicotine).
Intention to remain in an addiction treatment program until intervention completion (does not apply to healthy control participants).
Confident level of English language proficiency.

Exclusion

Any organic brain disorder (e.g. TBI, stroke).
Head injury resulting in skull fracture or loss of consciousness exceeding 30 minutes.
TMS contraindication (history of seizures, metallic cranial plates/screws or implanted device).
MRI contraindications (unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, claustrophobia).
Any psychotic disorder (Participants with other treated and stable psychiatric disorders will be included).
Presence of a condition that would render study measures impossible to administer or interpret.
Primary current substance use disorder diagnosis on a substance other than stimulants or cocaine, except for caffeine or nicotine.
Greater than 9 months abstinence from substance use (does not apply to healthy control participants).
Pregnancy or breastfeeding.

What this trial measures

  • TEP individual response2 hours

    Use TMS-evoked potentials (TEPs) to assess individual response to three TMS-EEG synchronization methods: random, peak, and trough.

  • Cognitive responseMeasured immediately after the iTBS

    Investigate the CSST task cognitive response to three TMS-EEG synchronization approaches during intermittent Theta Burst Stimulation (iTBS).