Lidocaine Infusion and Nerve Monitoring During Spine Surgery

This study is looking at how a lidocaine infusion affects nerve monitoring during spine surgery. Researchers want to see if giving lidocaine (a common numbing medicine) through an IV changes how doctors measure your nerve signals (Motor Evoked Potentials or MEPs) during surgery. You might be eligible if you are an adult having elective cervical or thoracolumbar spine surgery and already having nerve monitoring. The study will compare patients who receive a lidocaine infusion to those who receive a normal saline infusion. Success would mean understanding how lidocaine affects these nerve signals, which could help improve patient care during and after surgery. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 44 participants. It compares two groups: one receiving lidocaine infusion and another receiving normal saline infusion.
What's involved
Participants will receive either a lidocaine infusion or a normal saline infusion during their spine surgery. Nerve signals (MEPs and SSEPs) will be measured during the surgery.
Compensation
Not stated in the trial record.
Follow-up
Motor Evoked Potentials (MEPs) will be measured during the surgical procedure, for no more than 24 hours.

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NCT06792474

Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Dartmouth-Hitchcock Medical Center
~44 participants
Updated 2025-11-24 on ClinicalTrials.gov
What's tested:Lidocaine in SalineNormal saline

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Motor Evoked Potentials (MEPs)
Measured over Duration of the surgical procedure, no more than 24 hours
Spinal Disease
Anesthesia
Post Operative Pain
1 sites across 1 states
New Hampshire1

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Eligibility criteria

Inclusion

Patients undergoing elective cervical or thoracolumbar spine surgery with intraoperative neurophysiological monitoring

Exclusion

Inability to provide informed consent in English
Pregnancy (based on patient report or a positive test on the day of surgery)
Contraindication to lidocaine
Planned post-operative intubation
Current incarceration
  • Motor Evoked Potentials (MEPs)Duration of the surgical procedure, no more than 24 hours

    An endpoint of the final stimulation threshold for MEPs at the end of surgery.