Fidaxomicin vs. Vancomycin for C. Difficile in IBD
This study is looking at two different antibiotics, fidaxomicin and vancomycin, to see which is better at getting rid of *C. difficile* (a type of bacteria that can cause severe diarrhea) in people with Inflammatory Bowel Disease (IBD). You might be able to join if you are over 18, have an IBD diagnosis, and are scheduled for an outpatient colonoscopy. We want to see if these medicines are safe and effective at clearing *C. difficile* over 8 weeks. This study is currently recruiting 60 participants.
- Study design
- This is a randomized, double-blind study involving 60 participants. You would be randomly assigned to receive either fidaxomicin or vancomycin, and neither you nor the study team would know which medicine you are receiving.
- What's involved
- You would take medication for 10 days. Monitoring will continue through week 8, with some follow-up extending to week 26, including stool samples and recording symptoms.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for safety and effectiveness for 8 weeks after treatment ends, with some assessments continuing up to 26 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Use of Fidaxomicin Compared to Vancomycin for Decolonization of C. Difficile in Patients With Inflammatory Bowel Disease
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jessica Allegretti, MD, MPH · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital
Who to contact
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What this trial measures
- C. difficile decolonization8 weeks
Absence of C. difficile via PCR in Week 8 stool sample
- Safety and tolerability8 weeks
Subject incidence of treatment-emergent adverse events (including treatment-emergent adverse events for clinically significant changes in laboratory parameters and vital signs)