Fidaxomicin vs. Vancomycin for C. Difficile in IBD

This study is looking at two different antibiotics, fidaxomicin and vancomycin, to see which is better at getting rid of *C. difficile* (a type of bacteria that can cause severe diarrhea) in people with Inflammatory Bowel Disease (IBD). You might be able to join if you are over 18, have an IBD diagnosis, and are scheduled for an outpatient colonoscopy. We want to see if these medicines are safe and effective at clearing *C. difficile* over 8 weeks. This study is currently recruiting 60 participants.

Study design
This is a randomized, double-blind study involving 60 participants. You would be randomly assigned to receive either fidaxomicin or vancomycin, and neither you nor the study team would know which medicine you are receiving.
What's involved
You would take medication for 10 days. Monitoring will continue through week 8, with some follow-up extending to week 26, including stool samples and recording symptoms.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for safety and effectiveness for 8 weeks after treatment ends, with some assessments continuing up to 26 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06794944

Use of Fidaxomicin Compared to Vancomycin for Decolonization of C. Difficile in Patients With Inflammatory Bowel Disease

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Brigham and Women's Hospital
~60 participants
Updated 2025-11-03 on ClinicalTrials.gov
What's tested:Vancomycin (POC)Fidaxomicin

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
C. difficile decolonization
Measured over 8 weeks
+1 more outcome measured
Inflammatory Bowel Disease (IBD)
Clostridioides Difficile Infection
1 sites across 1 states
Massachusetts1
  • Jessica Allegretti, MD, MPH · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital

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  • C. difficile decolonization8 weeks

    Absence of C. difficile via PCR in Week 8 stool sample

  • Safety and tolerability8 weeks

    Subject incidence of treatment-emergent adverse events (including treatment-emergent adverse events for clinically significant changes in laboratory parameters and vital signs)