NCT06795035
Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution
Recruiting
Not specifiedAges 18+ObservationalThe Cleveland ClinicInvestigator-initiated
~70 participants
Updated 2025-07-31 on ClinicalTrials.gov
What's tested:Continuous Saline Thermodilution
At a glance
Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Microvascular resistance reserve (MRR)
Measured over At enrollment
Conditions
Where it's being run
1 sites across 1 statesOhio1
Study leadership
- Khaled Ziada, MD · PRINCIPAL_INVESTIGATOR · The Cleveland Clinic
Who to contact
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Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Adults (persons \>18 years old) presenting to Cleveland Clinic cardiac catheterization lab within 24 hours of symptom onset, with clinical and EKG findings concerning for STEMI, with intent to undergo emergent primary PCI, who have culprit artery identified on diagnostic angiography
Adults (persons \>18 years old) presenting to Cleveland Clinic cardiac catheterization lab for pharmaco-invasive management of failed fibrinolysis, with intent to undergo emergent PCI, who have culprit artery identified on diagnostic angiography
On-call treating interventional cardiologist is trained in the method of continuous saline thermodilution for coronary microvascular assessment
Exclusion
No evidence of coronary obstruction on diagnostic angiography (e.g., Takotsubo, myocarditis leading to STEMI activation).
Patients in hemodynamic shock
Culprit artery \<3.0 mm in diameter.
Culprit artery being a bypass graft
Patients physically unable to tolerate additional time required to conduct coronary microvascular testing after primary PCI.
Patients with eGFR \<30 mL/min/1.73m2 are excluded from contributing cardiac MRI data
Patients with standard contraindications to CMR (e.g., pacemakers, cochlear implants, certain prosthetic heart valves, certain surgical implants) are excluded from contributing cardiac MRI data
Unable to provide verbal and written consent
Pregnancy
What this trial measures
- Microvascular resistance reserve (MRR)At enrollment
Calculated index to assess coronary microvascular dysfunction (Q\_hyperemia/Q\_rest)\*(Pa\_rest/Pd\_hyperemia)