This study is looking at how a protein called PDE4B (phosphodiesterase-4B) changes in the brains of people with Alcohol Use Disorder (AUD). Researchers believe that people with AUD may have lower levels of PDE4B, especially during alcohol withdrawal. You would receive an injection of 18F-PF-06445974, followed by PET (Positron Emission Tomography) scans. This imaging helps measure the amount of PDE4B in your brain. The study aims to see if PDE4B levels are low during withdrawal and if they increase after 3-4 weeks of not drinking alcohol. This research could help develop better treatments for AUD. The study plans to enroll 30 participants, but its current status is unclear.

Study design

This is an interventional study planning to enroll 30 participants. It involves two PET scans over a 3-4 week period.

What's involved

You would stay in a clinic for 3 to 4 weeks for alcohol withdrawal. You would have two PET scans and MRI tests.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint, measuring distribution volume, is assessed at 36 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.