This study is looking at how menopause and aging affect your body's ability to handle heat. Researchers want to understand the role of estrogen in how pre- and postmenopausal women respond to heat stress. Participants will receive either Elagolix Oral Tablet (a medication that temporarily lowers estrogen), an Estradiol patch (which increases estrogen), or placebo (inactive) tablets and patches. The study will measure your skin blood flow, sweat rate, and core body temperature during heating experiments to see how these interventions affect your body's response. Women aged 42 to 64 can participate, but you cannot join if you have certain health conditions like Crohn's disease, use tobacco, or are currently on hormone therapy or hormonal contraceptives. The study aims to enroll 24 participants.

Study design

This is an interventional study with 24 participants. It compares the effects of Elagolix Oral Tablet, Estradiol patch, and placebo on body temperature regulation.

What's involved

You will undergo a medical screening including a physical exam and blood tests. You will complete 6 experimental trials, each involving passive and active heating experiments over an average of 3 weeks per intervention.

Compensation

Not stated in the trial record.

Follow-up

Your skin blood flow, local sweat rate, and core temperature will be monitored continuously during 3-hour heating experiments, with measurements taken over approximately 3 weeks for each intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.