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Improving Opioid Use Disorder Treatment in the Emergency Department

This study is testing a computer-based tool called EMBED to help emergency room doctors treat opioid use disorder (OUD) more effectively. EMBED helps doctors diagnose OUD and start patients on buprenorphine, a medication that helps with OUD, while they are still in the emergency department. The study also looks at ways to encourage nurses and doctors to use EMBED, and how to provide helpful resources to patients when they leave the hospital. The goal is to increase the number of patients with OUD who receive buprenorphine in the emergency room. You might be able to join if you are 18 or older, are in the emergency department, and have moderate to severe OUD. You cannot join if you are pregnant or already taking medication for OUD. This study is not currently open for new participants.

Study design
This study is an interventional study, meaning participants will receive specific interventions. It plans to enroll 1912 participants and uses a special multi-stage approach to refine the interventions.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will measure outcomes upon discharge from the ED (1 day) and for up to 18 months after the ED visit.

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NCT06799117

Adaptive Decision Support for Addiction Treatment Master

Recruiting
NAAges 18+InterventionalTreatment
Yale University
~1,912 participants
Updated 2026-06-11 on ClinicalTrials.gov
What's tested:EMBED CDSNurse prompt to complete COWSProvider PromptPatient facing materialsOptimized EMBEDName of Intervention

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of encounters with Buprenorphine initiation in the ED
Measured over Upon discharge from the ED, 1 day
+1 more outcome measured

Conditions

Opioid Use Disorder

Explore related trials

Opioid Use Disorder

Where it's being run

3 sites across 1 states
Connecticut3

Study leadership

  • Edward Melnick, MD, MHS · PRINCIPAL_INVESTIGATOR · Yale University

Who to contact

Edward Melnick, MD, MHS
[email protected]
203-785-4363
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Emergency department patient
18 years of age or older
Moderate to severe opioid use disorder

Exclusion

Under 18 years of age
Pregnant
Currently receiving medication for opioid use disorder

What this trial measures

  • Proportion of encounters with Buprenorphine initiation in the EDUpon discharge from the ED, 1 day

    Proportion of eligible encounters with buprenorphine administered in the Emergency Department (ED) and/or prescribed buprenorphine on discharge from the ED. Obtained from EHR data.

  • Proportion of alerted encounters with CDS engagementFrom ED visit through end of trial stage/cycle, up to 18 months

    Proportion of eligible encounters in the Emergency Department with an alert fired (silent or active) with CDS engagement. CDS engagement is defined as: OUD diagnosis entered via CDS, withdrawal assessment, readiness assessment, buprenorphine order/prescription placed, referral placed, or any flowsheet item completed.