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Pain Reprocessing Therapy for Chronic Knee Pain After Surgery

This study is looking at whether a new type of talk therapy, called Pain Reprocessing Therapy (PRT), can help adults who have ongoing knee pain after knee replacement surgery. PRT aims to help you understand pain differently, seeing it as something your brain can change, rather than a permanent problem with your knee. Researchers will compare PRT to usual care (what you're already doing for your pain) to see which is more effective. They want to know if PRT reduces pain, and how it affects things like anxiety, depression, and sleep. You could join if you are 18 or older, had knee replacement surgery at least three months ago without complications, and still have significant knee pain. The study is currently recruiting 110 participants.

Study design
This study will randomly assign participants to receive either Pain Reprocessing Therapy or continue with their usual care. It aims to enroll 110 participants.
What's involved
Participants will complete questionnaires about their pain and health. The record does not specify the number of visits or procedures.
Compensation
Not stated in the trial record.
Follow-up
Pain intensity will be measured at approximately 12, 18, and 26 weeks after you are assigned to a treatment group.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06800209

Pain Reprocessing Therapy in Post-Operative Knee Pain

Recruiting
PHASE2Ages 18+InterventionalTreatment
Weill Medical College of Cornell University
~110 participants
Updated 2026-08-05 on ClinicalTrials.gov
What's tested:Pain reprocessing therapy (PRT)Usual care

At a glance

Recruiting sites
1 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pain intensity
Measured over Approximately 12, 18, and 26 weeks post-randomization

Conditions

Pain, Chronic
Knee Pain Chronic

Explore related trials

Pain of joint of knee

NCT06800209

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Hospital for Special Surgery

    New York, New Yorkstudy coordinator listed

    Recruiting

  • University of Colorado Anschutz Medical Campus

    Aurora, Coloradono site contact published

    Active, not recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Cary Reid, MD, PhD · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University

Who to contact

Allina Nocon, PhD
[email protected]
212-774-2572
Email the study team

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Eligibility criteria

Inclusion

Patients are deemed eligible at 3 months post-operatively if: The patient completed a primary knee replacement \[surgery completed without complication and patient exhibits full mechanical joint function, as determined by the treating physician (good range of motion, stability, and wound healing; absence of swelling)\] and patient reports last week average knee pain ≥ 4 of 20 and at least two questions rated 'moderate' on A 12-item shortened version (ShortMAC) of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
Reported pre-operative chronic knee pain of at least 6 months duration prior to surgery
The procedure was a primary (not a revision) knee replacement
Proficient in English

Exclusion

Patients who are not willing to participate in a telehealth visit.
Patients with pre-op chronic pain but who do not have post-operative pain after the three month time period.
Active suicidal ideation with intent, recent history of suicide attempt, or self-harm behaviors within the past 5 years (including non-suicidal self-harm).
Recent history of inpatient psychiatric hospitalization within the past 5 years.
Active, current psychosis or mania.
Active, current substance abuse, or problems with substance abuse within the past 2 years.
Instability in living conditions or major interfering life events:
Major surgery or other major medical event planned in coming 6 months.
Uncertain whether they will have suitable conditions for telehealth appointments over the next 2 months, including access to a computer or tablet, reliable high-speed internet, and a quiet, comfortable room that is consistently available.
Major, interfering changes in employment or housing anticipated over the next 6 months.
Neurological conditions (e.g., Alzheimer's, dementia, mild cognitive impairment, Huntington's disease, multiple sclerosis, cerebral palsy). This will be case-by-case decision made by PI to determine if the condition may interfere with treatment and warrant exclusion.
Self-reported diagnosis of an autoimmune disease (e.g., rheumatoid arthritis, polymyalgia rheumatica, scleroderma, lupus, polymyositis, or another autoimmune disorder).
Currently or plan to be involved in lawsuits related to pain in next 6 months, currently or plan to apply for any disability payments related to the pain in next 6 months, or received legal settlement or other disability payments related to the pain over past 2 years.
Are unable or uncomfortable with completing a dry cap EEG.
Has had a history of abnormal EEGs.
Had bilateral TKA

What this trial measures

  • Pain intensityApproximately 12, 18, and 26 weeks post-randomization

    Last-week average pain intensity is assessed using the 5-item pain subscale of the 12-item shortened version (ShortMAC) of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The ShortMAC assesses pain severity and its impact on functioning. It consists of 12 total items, including 5 pain items and 7 pain interference items. The 5 pain items measure pain on a scale of 0-4, with 0 indicating no pain and 4 indicating extreme pain.