Comparing Norepinephrine and Phenylephrine to Prevent Kidney Injury After Surgery
This study is looking at which common medication, norepinephrine or phenylephrine, is better at preventing acute kidney injury (AKI) after major non-cardiac surgery. Low blood pressure (hypotension) during surgery is common and can lead to kidney problems. Both norepinephrine and phenylephrine are used to raise blood pressure, but it's not known which one is more effective at protecting your kidneys. You might be able to join if you are 18 or older, having surgery lasting at least 2 hours under general anesthesia, and receive vasopressors during surgery. The study aims to see if one medication leads to fewer cases of AKI within 7 days after surgery. The current recruitment status is unclear, but the study plans to enroll 18,000 participants.
- Study design
- This is an open-label, cluster-randomized, crossover study involving hospitals. Hospitals will switch between using phenylephrine or norepinephrine as the first-line vasopressor during different months.
- What's involved
- No additional lab tests or procedures will be required for the study beyond routine clinical care. Data will be collected from your electronic health record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Acute kidney injury will be measured at 7 days after surgery.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
At a glance
Conditions
Where it's being run
10 sites across 8 statesStudy leadership
- Sachin Kheterpal, MD MBA · PRINCIPAL_INVESTIGATOR · University of Michigan
- Matthieu Legrand, MD PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
- Allison Janda, MD · STUDY_DIRECTOR · University of Michigan
- Michael P Bokoch, MD PhD · STUDY_DIRECTOR · University of California, San Francisco
- Douglas Colquhoun, MB ChB, MSc, MPH · STUDY_DIRECTOR · University of Michigan
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Acute Kidney Injury (AKI)7 days
AKI will be defined by the change of serum creatinine based on the Kidney Disease Improving Global Outcomes (KDIGO) criteria.