Neuromodulation for Pulmonary Arterial Hypertension
This study is testing a new approach called low-level tragus stimulation for people with pulmonary arterial hypertension (PAH), a type of high blood pressure in the lungs. This stimulation uses a device placed on the ear to send signals through a nerve to the brain, which may help improve symptoms. Researchers want to see if this stimulation can improve your exercise ability and quality of life. You might be able to join if you are 18 to 90 years old, have Group 1 PAH, and are in WHO functional class II/III. The study plans to enroll 50 participants, but its current recruitment status is unclear.
- Study design
- This is a randomized, double-blind study comparing low-level tragus stimulation to a sham (inactive) stimulation, involving 50 participants.
- What's involved
- You would receive stimulation for 1 hour every day for 4 weeks. You will have tests like a 6-minute walk, vascular function testing, blood draws, and an echocardiogram at the beginning and after 4 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- You will be followed for 4 weeks after the stimulation begins, with final tests at that time.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Neuromodulation in Patients With Pulmonary Arterial Hypertension
At a glance
Conditions
NCT06802380
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Oklahoma health sciences Center
Oklahoma City, Oklahomastudy coordinator listed
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Tarun Dasari, MD · PRINCIPAL_INVESTIGATOR · University of Oklahoma
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Heart rate variability4 weeks
Change in the heart rate variability metrics. These are reflective of the autonomic tone and the imbalance. Investigators hypothesized that using low-level tragus stimulation in patients with pulmonary hypertension the heart rate variability will be favorably affected using low-level tragus stimulation compared to sham stimulation. Time domain metrics are usually measured using variation of the standard R-R interval on the EKG in milliseconds.