Motor-voice Assessment in Infants (MAMI) Observational Study

This observational study, called MAMI, is looking at how infants move and vocalize to find early signs of physical disabilities like Cerebral Palsy (a condition affecting movement and muscle tone) or other neurodevelopmental disorders. Researchers will observe behaviors in your child's natural environment using digital health assessments. They want to understand how voice patterns are connected to motor skills in infants, especially those at risk for conditions like Cerebral Palsy. The study aims to identify specific voice features in infants with newborn risk factors and see how these relate to their overall development and motor function. This study plans to enroll 46 infants.

Study design
This is an observational study with an unclear status, planning to enroll 46 participants. It involves behavioral observation in children's natural environments.
What's involved
You will be asked to upload 3-minute videos of your child at term-age, 3.5 months, and 9 months of age. At the 3.5-month and 9-month time points, you can choose to attend an optional in-person assessment with your child.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed at term-age, 3-months corrected age, and 9-months corrected age.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06807203

Motor-voice Assessment in Infants (MAMI)

Recruiting
Not specifiedUp to 10Observational
Ohio State University
~46 participants
Updated 2026-03-27 on ClinicalTrials.gov
What's tested:Behavioral observation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
General Movement Assessment
Measured over At term-age, 3- and 9-months corrected age.
+2 more outcomes measured
Cerebral Palsy Infantile
Pre-Term
Motor Delay
Neurodevelopmental Disorders
Autism Spectrum Disorder
1 sites across 1 states
Ohio1

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Eligibility criteria

Inclusion

gestational age of 24 0/7 - 41 6/7,
admitted to the NICU,
medically stable by 40 weeks of gestation (including off ventilator support),
born to mothers 18 - 43 years old at the time of birth,
one parent fluent in English.

Exclusion

diagnosis of a genetic syndrome (e.g. Trisomy 21),
musculoskeletal deformity,
failed hearing screen.
  • General Movement AssessmentAt term-age, 3- and 9-months corrected age.

    A non-invasive medical exam that evaluates an infant's spontaneous movements to identify neurological issues.

  • GMA-associated Motor Optimality ScoreAt term-age, 3- and 9-months corrected age.

    A numerical score derived from the General Movements Assessment (GMA), a method used to evaluate an infant's spontaneous movements, where a higher score indicates more optimal motor development and a lower score may suggest potential neurological concerns.

  • Voice acoustic analysis and number of vocalizationsAt term-age, 3- and 9-months corrected age.

    Fundamental frequency, ratio of voiced sound, shimmer, jitter, Harmonic-to-noise ratio, frequencies of the first four formants