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Sleep Restriction and Glucose Metabolism Study

This study aims to understand if insufficient sleep affects how men and women process sugar (glucose metabolism) differently. Many people don't get enough sleep, which can lead to health problems like diabetes. While we know lack of sleep can make it harder for the body to handle sugar, it's not clear if there are differences between men and women. This study will have participants sleep only 4 hours a night for a short period. Researchers will then measure their blood sugar (postprandial glucose response) and a hormone called GLP-1 to see how their bodies react. They are looking for healthy adults, aged 20-40, who are non-smokers and have regular sleep habits. The study is currently recruiting 32 participants.

Study design
This is an interventional study planning to enroll 32 healthy adults. It will compare how men and women respond to sleep restriction.
What's involved
You would need to spend 5 consecutive days and nights in a laboratory on two separate occasions, for a total of 10 days/nights. You will be asked to sleep only 4 hours per night during the sleep restriction period.
Compensation
Not stated in the trial record.
Follow-up
Your blood sugar and GLP-1 responses will be measured on Study Day 4 after sleep restriction.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06809023

Evaluation of Sex Differences in Glucose Metabolism in Response to Sleep Curtailment

Not Yet Recruiting
NAAges 20–40InterventionalBasic science
Brigham and Women's Hospital
~32 participants
Updated 2025-12-10 on ClinicalTrials.gov
What's tested:Sleep restriction

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Difference between men and women in postprandial glucose response after Sleep Restriction
Measured over Study Day 4 (Arm 1) vs. Study Day 4 (Arm 2)
+1 more outcome measured

Conditions

Sleep Deprivation
Sex Differences
Glucose Tolerance

Explore related trials

Sleep deprivation

Where it's being run

1 sites across 1 states
Massachusetts1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Healthy adults with conventional sleep-wake timing
Non-smokers
Completion of medical, psychological, and sleep screening tests
Able to spend 5 consecutive days/nights in the laboratory on two separate occasions (total of 10 days/nights in the laboratory)
Women must have a recent history of regular menstrual cycles

Exclusion

History of neurological or psychiatric disorder
History of sleep disorder or regular use of sleep-promoting medication
Current prescription, herbal, or over-the-counter medication use including hormonal birth control
Traveling across 2 or more time zones within past 3 months
Donating blood within past 8 weeks
Worked night or rotating shift work within past year
Hearing impairment, visual impairment
History of eye trauma or surgery
Drug or alcohol dependency

What this trial measures

  • Difference between men and women in postprandial glucose response after Sleep RestrictionStudy Day 4 (Arm 1) vs. Study Day 4 (Arm 2)

    Test the hypothesis that three nights of sleep curtailment increases postprandial glucose levels to a greater extent in women compared to men. Postprandial glucose will be assessed in response to a standard meal after Control and Sleep Restriction. The change in postprandial glucose from Control to Sleep Restriction will be compared between men and women.

  • Difference between men and women in postprandial GLP-1 response after Sleep RestrictionStudy Day 4 (Arm 1) vs. Study Day 4 (Arm 2)

    Test the hypothesis that three nights of sleep curtailment decreases postprandial GLP-1 levels to a greater extent in women compared to men. Postprandial GLP-1 levels will be assessed in response to a standard meal after Control and Sleep Restriction. The change in postprandial GLP-1 from Control to Sleep Restriction will be compared between men and women.