Pain Control After Craniotomy Surgery with Methadone or Remifentanil

This study is looking at ways to manage pain and improve recovery after brain surgery (craniotomy). Many patients experience moderate to severe pain after this type of surgery, which can lead to complications. This study compares two pain medications given through a vein (intravenous): Remifentanil and Methadone. Researchers want to see if Methadone, which has a longer-lasting pain-relieving effect, can improve your recovery in the first few days after surgery. They will measure your quality of recovery using a special questionnaire. You might be able to join if you are between 18 and 65 years old, are having a specific type of brain surgery, and meet other health criteria. The study is currently unclear on its recruitment status and plans to enroll 40 participants.

Study design
This is an interventional study comparing two different medications for pain control. It plans to enroll 40 adult participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your quality of recovery will be measured on postoperative days 1, 2, and 3 (24, 48, and 72 hours after surgery).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06810336

Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery

Recruiting
EARLY_PHASE1Ages 18–65InterventionalHealth services
University of Virginia
~40 participants
Updated 2026-05-04 on ClinicalTrials.gov
What's tested:RemifentanilMethadone

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Quality of recovery after surgery on postoperative day 1,2,3 using QoR-15 psychometrical questionnaire (range 0-150).
Measured over 24 hours, 48 hours, 72 hours
Brain Injury
Brain Tumors
Craniotomy Surgery
Pain
Postoperative
Postoperative Care
1 sites across 1 states
Virginia1

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  • Quality of recovery after surgery on postoperative day 1,2,3 using QoR-15 psychometrical questionnaire (range 0-150).24 hours, 48 hours, 72 hours

    The Quality of Recovery-15 (QoR-15) scale is a patient-reported outcome measurement of the quality of recovery after surgery and anesthesia. The scale ranges from 0 to 150, with a higher score indicating a better quality of recovery. A score of 0 indicates extremely poor quality of recovery, while a score of 150 indicates excellent quality of recovery. The QoR-15 score can be classified into four severity classes: excellent, good, moderate, and poor recovery.