Pain Management in Thoracic Surgery

This study is comparing two different methods for pain relief after lung cancer surgery: an Erector Spinae (ESP) Block using bupivacaine (Marcaine®) given before surgery, and an Intercostal nerve block using liposomal bupivacaine (Exparel®) given during surgery. The goal is to see which method provides better pain control. You may be able to join if you are between 18 and 90 years old, are having certain lung surgeries (video assisted pulmonary resection, pleurodesis, or decortication), and do not have allergies to local anesthetics. The study will measure how well your pain is controlled for up to 48 hours after surgery and how much pain medication you need for up to 72 hours after surgery. The study plans to enroll 120 participants.

Study design
This interventional study is comparing two different pain block methods. It plans to enroll 120 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pain control will be assessed for up to 48 hours after surgery. The amount of pain medication you need will be assessed for up to 72 hours after surgery.

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NCT06810375

Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery

Recruiting
PHASE3Ages 18–90InterventionalTreatment
George Washington University
~120 participants
Updated 2026-04-09 on ClinicalTrials.gov
What's tested:Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)Intercostal nerve block

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Postoperative pain control assessment
Measured over Up to 48 hours postoperatively
+1 more outcome measured
Lung Cancers
1 sites across 1 states
District of Columbia1

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Eligibility criteria

Inclusion

Video assisted pulmonary resection, pleurodesis or decortication

Exclusion

Allergy to local anesthetics
Patient undergoing bilateral surgery
Surgery is emergent as deemed by the principal investigator
  • Postoperative pain control assessmentUp to 48 hours postoperatively

    Study team will assess postoperative pain scores at 6, 12, 24 and 48 hours (Minimum numerical pain score of 0 and a maximum of 10)

  • Morphine equivalent assessmentUp to 72 hours postoperatively

    Study team will collect information on all administered pain medications to calculate morphine equivalents