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PEDI PANDAS Study: Understanding PANS and PANDAS in Children

This study, called PEDI PANDAS, is looking at children aged 3 to 17 who have Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) or Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus (PANDAS). The main goal is to see if it's possible to successfully enroll and keep children in a study that tracks how these conditions develop over time. Researchers want to understand how often these conditions occur and what their natural course is. You could be eligible if you are a child between 3 and 17, and you and your parent/guardian can complete study activities in English. Your family also needs to plan to receive care at UW Health or Dartmouth Health for at least one year. The study aims to recruit and follow 30 children for one year.

Study design
This is an observational study, meaning participants will be followed without receiving any specific interventions from the study. It aims to enroll 30 participants.
What's involved
You would need to complete all study activities in English and plan to be followed within UW Health or Dartmouth Health for at least one year. You will be followed for one year.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06811935

PEDI Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcus Study

Recruiting
Not specifiedAges 3–17Observational
University of Wisconsin, Madison
~30 participants
Updated 2026-01-27 on ClinicalTrials.gov

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of Eligible Participants Enrolled
Measured over up to 12 months

Conditions

PANS
PANDAS

Explore related trials

PANDASPeripheral Nerve Stimulation

NCT06811935

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Dartmouth Hitchcock Medical Center

    Lebanon, New Hampshireno site contact published

    Recruiting

  • UW School of Medicine and Public Health

    Madison, Wisconsinno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Ellen R Wald, MD · PRINCIPAL_INVESTIGATOR · UW School of Medicine and Public Health

Who to contact

Pediatric Clinical Research Coordination
[email protected]
(608) 228-4940
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Child age 3-17 years old
Child and their parent/guardian are able to complete all study activities in English
Potential participant's family plans to be followed within UW Health or Dartmouth Health for at least one year
Pediatric patient who is a current member of the primary care population at either UW Health or Dartmouth Health
Abrupt onset of symptoms (within 7 days) occurring in the past 3 months. Willing to come in-person for at least the baseline visit.
Suspected diagnosis of PANS or PANDAS based on published criteria:
PANS: (A) Abrupt, dramatic, overnight onset of obsessive compulsive disorder (OCD) or severely restricted food intake; (B) concurrent abrupt onset of additional severe neuropsychiatric symptoms from at least 2 of the following 7 categories:
PANDAS
Presence of OCD and/or tic disorder
Pre-pubertal onset of symptoms (i.e., 3-12 years old)
Episodic course characterized by very acute and severe onset and dramatic symptom exacerbations
Neurologic abnormalities present during symptom exacerbations-motoric hyperactivity and adventitious movements
Temporal relationships between group A streptococcus (GAS) infections and symptom exacerbations
Abrupt onset of symptoms (within 7 days) occurring in the past 4 months.
Confirmed diagnosis of PANS or PANDAS based on published criteria (see above).

Exclusion

History of tics, OCD or food restriction/avoidance that contradicts a history of sudden onset or was present before the onset of this investigation
Current symptom(s) of Pica
Previous participation in the study
Not suitable for study participation at the discretion of the site investigator (e.g., the child does not have verbal or cognitive ability adequate for self-report assessment)
Patient or family is unable to complete the study questionnaires or procedures in English as the primary language

What this trial measures

  • Percentage of Eligible Participants Enrolledup to 12 months

    To demonstrate that the methods of recruitment are effective, the aim is to enroll 85 percent of children with PANS/PANDAS who meet preliminary eligibility criteria for the study.