This research study is looking at how different people respond to sitagliptin, a medication approved to treat diabetes. We are seeking healthy, non-diabetic volunteers from the Old Order Amish community in Lancaster, PA, aged 18 and older. The study aims to understand how sitagliptin affects early insulin release and glucose tolerance. You would participate in a 7-week study with two clinic visits, 4-6 weeks apart. During these visits, you'll have an oral glucose tolerance test (OGTT), where you drink a sugary liquid and have blood drawn to measure glucose and insulin levels. The study is currently unclear on its recruitment status.

Study design

This is an interventional study planning to enroll 400 participants. It is not specified if it's randomized or blinded.

What's involved

You would participate in a 7-week study with two clinic visits, 4-6 weeks apart. Each clinic visit will last about 5 hours and include an oral glucose tolerance test (OGTT) and other blood tests.

Compensation

Not stated in the trial record.

Follow-up

The primary goals are measured at 6 weeks after starting sitagliptin, focusing on insulin secretion and glucose tolerance changes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.