Psilocybin-Assisted Therapy for Physician Burnout

This study is looking at Psilocybin-Assisted Therapy (PAT) to help UCSD physicians who are experiencing burnout. PAT combines a single 25 mg dose of psilocybin, a naturally occurring compound, with psychological support. Researchers want to see if this therapy is safe, practical, and can help reduce burnout symptoms. To join, you must be a UCSD faculty physician between 21 and 70 years old, have experienced burnout symptoms for over six months, and not have a history of serious mental illness or substance use disorder. The main goal is to measure changes in your well-being using the Stanford Professional Fulfillment Index (PFI) from when you start until 12 weeks after the study ends. This study is currently unclear on its recruitment status.

Study design
This is an open-label study, meaning both you and the researchers will know what treatment you are receiving. It involves a small group of 10 participants.
What's involved
You would participate in preparatory therapy sessions, receive a single dose of psilocybin, and then have post-treatment integration sessions.
Compensation
Not stated in the trial record.
Follow-up
Your well-being will be measured from enrollment until 12 weeks after the study ends.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06814522

Psilocybin-Assisted Therapy for Physician Well-Being and Burnout

Recruiting
PHASE1Ages 21–70InterventionalTreatment
University of California, San Diego
~30 participants
Updated 2026-09-02 on ClinicalTrials.gov
What's tested:Psilocybin, [3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphateReal-time Biofeedback

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Stanford Professional Fulfillment Index (PFI)
Measured over From enrollment until end of study at 12 week follow-up.
Burnout
Burnout, Healthcare Workers

NCT06814522

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • UC San Diego

    San Diego, Californiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Opens a ready-to-send draft in your own email app — review before sending.

  • Stanford Professional Fulfillment Index (PFI)From enrollment until end of study at 12 week follow-up.

    Assessment used to determine degree/severity of burnout.