Ketone Supplement and Alcohol Effects on Brain Metabolism
This study is looking at how a ketone supplement called Kenetik and an alcoholic beverage affect your brain. Researchers want to understand changes in certain brain chemicals (Nicotinamide adenine dinucleotide, Glutamate, and Gamma-aminobutyric acid) after you take Kenetik or drink alcohol. You might be able to join if you are between 21 and 65 years old and have had at least two alcoholic drinks on one day in the past month. The study aims to see the immediate effects of Kenetik compared to no intervention on these brain chemicals, measured at different times after taking the supplement. The study plans to enroll 60 participants.
- Study design
- This interventional study involves 60 participants who will randomly receive Kenetik, an alcoholic beverage, or no intervention, each on a separate visit.
- What's involved
- You will have a screening visit, including a medical history, physical exam, and blood draw. You will then undergo three identical MRI visits, each after a single dose of Kenetik, an alcoholic beverage, or no intervention.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary effects are measured at 45, 60, and 75 minutes after intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effects of Ketone Supplement and Alcohol on Brain Metabolism
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Corinde Wiers, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
Who to contact
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What this trial measures
- To examine the acute effects of ketone supplements compared to no intervention on Nicotinamide adenine dinucleotide levels in the brain.60 minutes
Use MRI imaging to measure the amount of Nicotinamide adenine dinucleotide levels in the brain measured in mmol/L in participants after receiving ketone supplement intervention compared to no intervention.
- To examine the acute effects of ketone supplements compared to no intervention on brain Glutamate levels.45 minutes
Use MRI imaging to measure the amount of Glutamate levels in the brain measured in mmol/L in participants after receiving ketone supplement intervention compared to no intervention.
- To examine the acute effects of ketone supplements compared to no intervention on brain Gamma-aminobutyric acid levels.75 minutes
Use MRI imaging to measure the amount of Gamma-aminobutyric acid levels in the brain measured in mmol/L in participants after receiving ketone supplement intervention compared to no intervention.