Evaluating ePUHRT With Brachytherapy Boost for Prostate Cancer

This study is testing a new way to treat prostate cancer by combining two types of radiation therapy: Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePUHRT), which is external radiation, and High Dose Rate Brachytherapy Boost, which is internal radiation where a doctor places a small tube or balloon in the tumor. The goal is to see how well patients tolerate this combined treatment and if it causes side effects. Researchers will measure the percentage of participants who experience acute (short-term) urinary or genital side effects of grade 2 or higher within 3 months. This study is for men aged 18 or older with unfavorable intermediate, high, or very high-risk prostate cancer. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 31 men with prostate cancer. It is not specified if it is randomized or blinded.
What's involved
Participants will receive ePUHRT 5Gy x 5 fractions delivered on noncontiguous weekdays, along with a single HDR boost of 15Gy.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for acute urinary or genital side effects for at least 3 months after treatment.

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NCT06817668

Evaluating Tolerability of ePUHRT With Brachytherapy Boost

Recruiting
NAAges 18+InterventionalTreatment
Indiana University
~31 participants
Updated 2025-09-26 on ClinicalTrials.gov
What's tested:ePURT 5Gy x 5 fractions with single HDR boost of 15Gy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Percentage of participants with acute grade ≥ 2 GU toxicity
Measured over 3 months
Prostate Cancer
1 sites across 1 states
Indiana1
  • Omar Ishaq, MD · PRINCIPAL_INVESTIGATOR · Indiana University Simon Comprehensive Cancer Center

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  • Percentage of participants with acute grade ≥ 2 GU toxicity3 months

    Physician-reported acute grade ≥ 2 GU toxicity at 3 months post ePUHRT with HDR boost measured by CTCAE version 5.