NCT06817902
TMS Pilot in Early AD II
Enrolling by Invitation
NAAges 40–90InterventionalTreatmentHealthPartners InstituteInvestigator-initiated
~6 participants
Updated 2026-01-07 on ClinicalTrials.gov
What's tested:Intermittent theta burst stimulation active coilSham coil
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Effect of TBS on cognition between and within subjects using Repeatable Battery for the Assessment of Neuropsychological Status Update (RBANS)
Measured over baseline, 7 weeks
Conditions
Where it's being run
1 sites across 1 statesMinnesota1
Study leadership
- Bhavani Kashyap, MBBS, PhD · PRINCIPAL_INVESTIGATOR · HealthPartners Institute
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Established diagnosis of Mild cognitive impairment (MCI)/mild AD
Evidence for central nervous system (CNS) amyloidosis (e.g., Amyloid Positron Emission Tomography (PET) or Cerebrospinal fluid (CSF) biomarkers consistent with AD)
Prior brain imaging performed
Mini Mental Status Examination (MMSE) \>24
Clinical Dementia Rating (CDR) 0.5-1
Stable dose of cholinesterase inhibitors and memantine for at least one month
Subjects are between 40-90 years of age
Exclusion
Non-AD dementia including, but not limited to, Lewy body dementia, frontotemporal dementia, vascular dementia, Jakob-Creutzfeldt disease, etc.
Inability to tolerate resting state-function magnetic resonance imaging (rs-fMRI)
Contraindication of rs-fMRI due to implants or metal
Seizure disorder
What this trial measures
- Effect of TBS on cognition between and within subjects using Repeatable Battery for the Assessment of Neuropsychological Status Update (RBANS)baseline, 7 weeks
Average change of RBANS total score in TMS arm compared to the average change in RBANS total score in the sham arm. Range \[-160 to 160\]. Positive comparison of TMS arm to sham arm indicates increased cognitive scores in TMS arm.