Comparing Antiplatelet Strategies After Stent Placement (PCI)

This study is comparing two ways to reduce bleeding risk in patients who have had a stent placed in their heart (percutaneous coronary intervention or PCI) due to coronary artery disease. After PCI, patients typically take two antiplatelet medicines (dual antiplatelet therapy or DAPT) like aspirin and prasugrel or ticagrelor. This trial looks at whether reducing the dose of prasugrel (from 10 mg to 5 mg) or switching from a stronger antiplatelet to a weaker one (clopidogrel 75 mg) is more effective at preventing blood clots while lowering bleeding risk. The main goal is to measure how well platelets are working after about a month. You may be able to join if you are 18 or older, have had PCI, and are currently taking aspirin with either prasugrel (10 mg) or ticagrelor (90 mg). The study plans to enroll 78 participants, but its current status is unclear.

Study design
This is an interventional study comparing two different antiplatelet treatments. It plans to enroll 78 participants.
What's involved
Participants will take either clopidogrel 75 mg or prasugrel 5 mg once daily for 30 ± 5 days. Platelet reactivity will be measured at the end of this period.
Compensation
Not stated in the trial record.
Follow-up
Platelet reactivity will be measured at 30 ± 5 days after starting the study medication.

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NCT06821191

Comparison of Dual Antiplatelet Therapy De-escalation by Dose Reduction Versus Switching in Patients Undergoing PCI: The Switching Antiplatelet-8 (SWAP-8) Study

Recruiting
PHASE4Ages 18+InterventionalTreatment
University of Florida
~78 participants
Updated 2026-05-12 on ClinicalTrials.gov
What's tested:clopidogrel 75 mgPrasugrel 5 mg

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Platelet reactivity measured by VerifyNow
Measured over 30±5 days
Coronary Artery Disease
1 sites across 1 states
Florida1

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  • Platelet reactivity measured by VerifyNow30±5 days

    The primary endpoint of the study will be to establish non-inferiority by comparing PRU levels, determined using the VerifyNow system, between de-escalation through dose reduction to low-dose prasugrel (5 mg qd) and de-escalation through switching to standard-dose clopidogrel (75 mg qd) at trough levels.