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Comparing Stroke Triage Strategies for Large Vessel Occlusion

This study, called the DIRECT trial, is comparing two ways to treat adults who might be having a severe type of stroke called a large vessel occlusion (LVO) stroke. These strokes happen when a major blood vessel in the brain is blocked. Researchers want to see if taking patients directly to a special room for treatment (called the neurointerventional angiography suite) is better than the usual way, which involves first going to the emergency department (ED). The study will look at how well people recover and if they have less disability 90 days after their stroke. You might be able to join if you are 18 or older, show signs of an LVO stroke, have a certain stroke severity score (NIHSS of 10 or higher), and arrive at the hospital within 7 hours of your symptoms starting. The study is currently unclear on its recruitment status.

Study design
This interventional study plans to enroll 2039 participants. It compares two different approaches to stroke care.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed to measure global disability at 90 days (±14 days) after their stroke.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06825897

Delay AvoIding Primary Evaluation for ThRombectomy of Acute StrokE Patients With Large Vessel OCclusion in the Angiography SuiTe

Recruiting
NAAges 18+InterventionalTreatment
Santiago Ortega Gutierrez
~2,039 participants
Updated 2026-03-13 on ClinicalTrials.gov
What's tested:Conventional Triage for Mechanical ThrombectomyDirect Transfer to Angiography Suite (DTAS

At a glance

Recruiting sites
5 of 6 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Global Disability at 90 Days
Measured over 90 days (±14 days)

Conditions

Stroke, Acute

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NCT06825897

Where you'd take part

This study runs at 6 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Henry Ford Health System

    Detroit, Michiganstudy coordinator listed

    Recruiting

  • HMH Hackensack University Medical Center

    Hackensack, New Jerseystudy coordinator listed

    Recruiting

  • The Research Foundation for SUNY on behalf of University at Buffalo

    New York, New Yorkstudy coordinator listed

    Recruiting

  • The University of Texas Health Science Center at Houston

    Houston, Texasstudy coordinator listed

    Recruiting

  • University of Iowa

    Iowa City, Iowastudy coordinator listed

    Not yet recruiting

  • University of Michigan Health-West

    Wyoming, Michiganstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Santiago Ortega, MD · PRINCIPAL_INVESTIGATOR · University of Iowa
  • Tudor Jovin, MD · PRINCIPAL_INVESTIGATOR · Cooper University Health Care

Who to contact

Santiago Ortega, MD
[email protected]
319-384-5628
Email the study team

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What this trial measures

  • Global Disability at 90 Days90 days (±14 days)

    Global disability will be measured using the disability-weighted modified Rankin Scale (dw-mRS) at 90 days (±14 days) post-stroke. The dw-mRS is a validated tool assessing the severity of disability across seven levels, from no symptoms (0) to severe disability or death (6). This outcome evaluates whether the direct transfer to the angiography suite (DTAS) strategy results in improved functional outcomes compared to the conventional triage strategy.