At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure
This study is looking at how an at-home cardio-oncology rehabilitation (CORE) program can help adolescent cancer survivors who are at risk for heart failure. The program involves at least 60 minutes of physical activity each day, including vigorous exercise and strengthening activities at least three times a week. The goal is to see if this program improves your heart fitness and overall well-being. Researchers also want to understand how well participants stick to the exercise plan and what resources are most helpful. You may be able to join if you are between 10 and 21 years old, have a history of certain cancer treatments, are in remission, and meet specific heart fitness criteria. The study aims to measure changes in heart fitness after six months.
- Study design
- This is an interventional study planning to enroll 20 participants. The study is testing a behavioral intervention called cardio-oncology rehabilitation.
- What's involved
- You would participate in a 6-month exercise intervention, which includes at least 60 minutes of physical activity daily, with vigorous-intensity and strengthening activities at least 3 days per week.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your cardiovascular fitness will be measured at the beginning of the study and again after 6 months.
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At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Jennifer Su, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital Los Angeles
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in cardiovascular fitness after completion of a 6-month exercise intervention.Baseline to 6 months
Peak VO2% (exercise capacity) as measured by cardiopulmonary exercise testing.
- Change in cardiovascular fitness after completion of a 6-month exercise intervention.Baseline to 6 months
Ve/VCO2 slope (predictor of cardiac mortality) as measured by cardiopulmonary exercise testing.
- Change in cardiovascular fitness after completion of a 6-month exercise intervention.Baseline to 6 months
Chronotropic response (heart rate response to exercise) as measured by cardiopulmonary exercise testing.
- Change in cardiovascular fitness after completion of a 6-month exercise intervention.Baseline to 6 months
Blood pressure response to exercise as measured by cardiopulmonary exercise testing.
- Change in cardiac function after completion of a 6-month exercise intervention.Baseline to 6 months
Cardiac function will be assessed via echocardiogram.
- Change in cardiac rhythm after completion of a 6-month exercise intervention.Baseline to 6 months
Cardiac rhythm will be assessed via EKG.
- Change in cardiac stress after completion of a 6-month exercise intervention.Baseline to 6 months
Cardiac stress will be assessed via NT-proBNP level.
- Average change in triglyceride level as measured from baseline to 6 months.Baseline to 6 months
Triglyceride (mg/dL) will be measured.
- Average change in total cholesterol level as measured from baseline to 6 months.Baseline to 6 months
Total cholesterol (mg/dL) will be measured.
- Average change in high density lipoprotein level as measured from baseline to 6 months.Baseline to 6 months
High density lipoprotein (HDL) (mg/dL) will be measured.
- Average change in low density lipoprotein as measured from baseline to 6 months.Baseline to 6 months
Low density lipoprotein (LDL) (mg/dL) will be measured.
- Average change in very low density lipoprotein as measured from baseline to 6 months.Baseline to 6 months
Very low density lipoprotein (VLDL) (mg/dL) will be measured.