This study is looking at how different ways of taking aspirin might help pregnant people at high risk for preeclampsia (a serious blood pressure condition) and preterm birth (birth before 37 weeks of pregnancy). Researchers want to see if taking 162mg of aspirin once a day works better than taking 81mg twice a day (every 12 hours) to prevent these problems. You might be able to join if you are 16-55 years old, are less than 16 weeks pregnant with one baby, and have certain risk factors for preeclampsia. The main goal is to see how well aspirin thins the blood, measured by a test called PFA-100 epinephrine closure time, 2-4 weeks after you start taking it. The current recruitment status is unclear.

Study design

This is an unblinded randomized study, meaning you and the researchers will know which aspirin dose you are taking. It plans to enroll 400 participants.

What's involved

You would be enrolled before 16 weeks of pregnancy and have your blood thinning response measured 2-4 weeks after starting aspirin, and again at 28-32 weeks of pregnancy.

Compensation

Not stated in the trial record.

Follow-up

Your blood thinning response will be assessed at 2-4 weeks after aspirin initiation and again at 28-32 weeks gestation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.