This study, called The ROAR Study, is looking at how "oxidative stress" (an imbalance of harmful molecules in the body) might affect reproduction and the success of In Vitro Fertilization (IVF). Researchers will measure markers of oxidative stress in your follicular fluid (fluid from the ovaries), semen (if applicable), and blood. They will then compare these measurements to your IVF and pregnancy outcomes. You may be able to join if you are a woman aged 18-43, planning preimplantation genetic screening (PGS) for aneuploidy (a type of genetic testing for embryos), and are a registered patient at UCSF Center for Reproductive Health. Your male partner, if applicable, must also be 18 or older. The study aims to understand if oxidative stress affects how well embryos develop and the chances of successful implantation. The study is currently unclear on its recruitment status and plans to enroll 1100 participants.

Study design

This is an observational study, meaning researchers will observe and collect information without providing specific treatments. It plans to include 1100 participants.

What's involved

You and your partner must both be physically present on the day of egg retrieval for diagnostic tests. Researchers will measure oxidative stress markers in your follicular fluid, semen, and blood.

Compensation

Not stated in the trial record.

Follow-up

Your implantation rate will be measured from enrollment until all embryos are transferred, which can be anywhere from 8 weeks to 1 year, or sometimes longer if pregnancy is achieved.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.