Aquagenic Wrinkling Prediction Study

This observational study is looking into whether a simple procedure called aquagenic wrinkling can help identify people who carry the gene for cystic fibrosis (CF). Aquagenic wrinkling is when your palms wrinkle quickly after being in water. You'll be asked to soak your hands in a water bath for up to 20 minutes, and researchers will observe how your hands respond. The study aims to see if human observation and machine learning can accurately detect this wrinkling. We are looking for 2000 participants between 18 and 24 years old who are interested in CF carrier research. You cannot participate if you have CF, diabetes, hyperhidrosis (excessive sweating), Raynaud's, or certain hand conditions.

Study design
This is an observational study with a planned enrollment of 2000 participants. It is not a drug trial, but rather investigates a procedure.
What's involved
You will complete one visit where your hands will be submerged in a water bath for one minute, and photographs will be taken.
Compensation
Not stated in the trial record.
Follow-up
Observations of wrinkling will be measured for up to 20 minutes during your single visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06831110

Aquagenic Wrinkling Prediction

Recruiting
Not specifiedAges 18–24Observational
University of Iowa
~2,000 participants
Updated 2026-06-04 on ClinicalTrials.gov
What's tested:Aquagenic Wrinkling

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Human Observation of Wrinkling
Measured over Up to 20 minutes
+1 more outcome measured
Aquagenic Wrinkling of Palms
Carrier State
1 sites across 1 states
Iowa1
  • Philip M Polgreen, MD · PRINCIPAL_INVESTIGATOR · University of Iowa

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Interested in participating in other CF Carrier-related research studies.

Exclusion

CF patient status
Unable to speak English
Unable to provide written informed consent
Prisoner status
An open wound on either hand
A tattoo on either hand
Missing any portion of either hand
Diagnosis of Diabetes
Diagnosis of Hyperhidrosis
Diagnosis of Raynaud's Disease
Diagnosis of Atopic Dermatitis
Regularly taking ACE inhibitors or angiotensin receptor blockers
  • Human Observation of WrinklingUp to 20 minutes

    Photos of hands will be scored on a scale of 0 (no wrinkling) to 4 (severe wrinkling) at each minute by human observers.

  • Machine-Learning Observation of WrinklingUp to 20 minutes

    Photos of hands will be scored by a machine-learning algorithm at each minute.