Observational Study of Heart Disease in NFL Alumni

This study, called the GAMEFILM Registry, is looking at heart disease (Coronary Artery Disease or CAD) in retired NFL players. It uses a special X-ray test called Coronary Computed Tomography Angiography (CCTA) to create detailed 3D pictures of the heart's blood vessels. The goal is to see how common and severe CAD is in this group. To join, you must be a retired NFL player. The study will be considered successful if it identifies participants with CAD based on the CCTA results within 24 hours. The current recruitment status is unclear, but about 300 participants are planned.

Study design
This is an observational study involving approximately 300 retired NFL players across about 20 sites in the US.
What's involved
You would undergo a Coronary Computed Tomography Angiography (CCTA) test.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint measures CAD at 24 hours from when the CCTA was taken.

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NCT06831409

Using CTA Measures to Define Cardiac Risk In NFL Alumni

Recruiting
Not specifiedAll AgesObservational
HeartFlow, Inc.
~300 participants
Updated 2025-08-26 on ClinicalTrials.gov
What's tested:Coronary computed tomography angiography

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Participants with CAD
Measured over 24 hours from the time CCTA was taken
Coronary Artery Disease (CAD)
Heart Disease
Coronary Atherosclerosis
1 sites across 1 states
Colorado1
  • Jeffrey Boone · PRINCIPAL_INVESTIGATOR · Boone Heart Institute

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Retired NFL player

Exclusion

CCTA not successfully processed for FFRct and AI-Plaque
  • Participants with CAD24 hours from the time CCTA was taken

    The proportion of participants with coronary artery disease demonstrated on coronary computed tomography angiography (CCTA).