An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

{ "Study of VX-880 for Type 1 Diabetes with a Kidney Transplant", "This study is looking at a treatment called VX-880 for people who have Type 1 Diabetes (T1D) and have also had a kidney transplant. VX-880 is given by infusion into a vein in the liver. The main goal is to see if VX-880 can help participants become independent of insulin one year after receiving the treatment. Researchers will also check how safe VX-880 is and how well people tolerate it. You might be able to join if you are between 18 and 65 years old, have had T1D for at least 5 years and rely on insulin, and are on a stable regimen of certain immunosuppression medicines (like tacrolimus and mycophenolate). The study plans to enroll 10 participants, but its current status is unclear.", "design": "This is an interventional study, meaning participants will receive a specific treatment. It aims to enroll 10 participants.", "commitments": "You would need to have a clinical history of Type 1 Diabetes with at least 5 years of insulin dependence and be on a stable immunosuppression regimen for at least 4 weeks. You would also need to use a continuous glucose monitor (CGM) for at least 4 weeks before screening and be willing to use it throughout the study.", "compensation": "Not stated in the trial record.", "follow_up": "The primary outcome is measured at 1 year after the VX-880 infusion, suggesting follow-up for at least that long.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT06832410

An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant

Recruiting
PHASE3Ages 18–65InterventionalTreatment
Vertex Pharmaceuticals Incorporated
~10 participants
Updated 2026-03-23 on ClinicalTrials.gov
What's tested:Biological/Vaccine

At a glance

Recruiting sites
7 of 7 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of Participants who are Insulin Independent
Measured over At 1 year After VX-880 infusion
Type 1 Diabetes
Kidney Transplant
7 sites across 4 states
Pennsylvania2
Canada2
Saudi Arabia2
Wisconsin1

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Eligibility criteria

Inclusion

Clinical history of T1D with greater than or equal to (≥)5 years of insulin dependence
Taking a stable immunosuppression regimen of tacrolimus and mycophenolate mofetil, mycophenolate sodium, or sirolimus for at least 4 weeks
Consistent use of continuous glucose monitor (CGM) for at least 4 weeks before Screening and willingness to use CGM for the duration of the study

Exclusion

Prior islet cell transplant, organ transplant (other than kidney transplant), or cell therapy, except prior pancreatic graft that failed within the first 4 weeks
Participants had \>1 kidney transplant procedure
  • Proportion of Participants who are Insulin IndependentAt 1 year After VX-880 infusion