This is a Phase I study looking at the safety and effects of combining Hydroxytyrosol (HT) with standard 5-Fluorouracil (5FU)-based chemotherapy (FOLFIRI/FOLFOX + Biologics) for people with advanced or metastatic colorectal cancer. You would take HT capsules daily for two weeks before starting chemotherapy, and continue taking them daily while on chemotherapy until your disease progresses. The main goal is to understand how safe this combination is, what side effects it might cause, and how your body handles the drugs. We are looking for about 33 participants who have advanced or metastatic colorectal cancer and are eligible for first-line 5FU-based therapy.

Study design

This is a Phase I interventional study planning to enroll 33 participants. The study is testing a combination of drugs.

What's involved

You would take Hydroxytyrosol capsules daily for two weeks before starting chemotherapy, and continue daily while receiving FOLFIRI/FOLFOX + Biologics chemotherapy until your disease progresses.

Compensation

Not stated in the trial record.

Follow-up

Your safety, toxicity, and how your body handles the drugs will be measured through study completion, up to 2 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.