Photobiomodulation for Head and Neck Cancer-Related Lymphedema

This study is investigating if photobiomodulation therapy (PBMT), using the RianCorp LTU-904 Portable Laser Therapy Unit, can help treat chronic lymphedema (swelling) in the head and neck for people who have had head and neck cancer. You may be able to join if you are over 18, have had head and neck cancer, and have chronic lymphedema that has lasted at least 6 months and affects at least two areas, with at least one being moderately severe. The researchers will measure the severity of your external lymphedema to see if the treatment is successful. The study aims to enroll 150 participants, but its current status is unclear.

Study design
This interventional study plans to enroll 150 participants. It will compare an active laser device to a sham (inactive) laser device.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 3, 6, 9, and 12 months after the intervention ends.

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NCT06837480

Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema

Recruiting
NAAges 18+InterventionalTreatment
Abramson Cancer Center at Penn Medicine
~150 participants
Updated 2026-06-23 on ClinicalTrials.gov
What's tested:LTU-904 Portable Laser Therapy Unit (active laser device)LTU-904 Portable Laser Therapy Unit (sham/inactive laser device)

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total Severity of External Lymphedema
Measured over Pre-intervention, after 12 sessions, after 18 sessions (end-of-intervention), 3-, 6-, 9-and 12-month post-intervention
Head and Neck Cancer
Lymphedema of the Head and Neck
2 sites across 2 states
Pennsylvania1
Tennessee1

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  • Total Severity of External LymphedemaPre-intervention, after 12 sessions, after 18 sessions (end-of-intervention), 3-, 6-, 9-and 12-month post-intervention

    Head and Neck Lymphedema and Fibrosis Assessment Criteria. External lymphedema is measured by HN-LEF Assessment Criteria. The total external lymphedema severity score is calculated by summing the severity score of each site (total 9 sites, severity score ranging from 0-27). For each site, the severity of LEF includes no lymphedema (=0), mild (=1), moderate (=2), and severe (=3). Change in total severity of external lymphedema from baseline to 12-month post-intervention visits. A larger reduction in this score means more reduction in the severity of external lymphedema.