Study on Physical Inactivity, Glucose, and Vascular Health
This study is looking at how short periods of reduced physical activity (RPA) affect your body's ability to control blood sugar (glucose) and the health of your blood vessels. Researchers want to understand if your current fitness level and body fat (adiposity) play a role in how your body recovers after being less active. The study involves a three-week period where you first maintain your normal activity, then reduce it for one week. Success will be measured by changes in your daily physical activity, blood sugar levels after a sugary drink (Oral Glucose Tolerance Test), and continuous blood sugar monitoring. This study is currently unclear on its recruitment status and aims to enroll 48 participants aged 18 to 40 who are generally active and can ride an e-scooter.
- Study design
- This is an interventional study planning to enroll 48 participants. It involves a structured period of reduced physical activity.
- What's involved
- You would participate in a three-week study. This includes one week of normal activity, followed by one week of reduced physical activity, with measurements taken at various points.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements for glucose control and daily physical activity will be taken for up to 3 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Interactive Roles of Cardiorespiratory Fitness and Adiposity on Glucose and Vascular Control After Physical Inactivity
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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What this trial measures
- Changes in Daily Physical Activity3 weeks
Accelerometers will be use to measure changes in daily physical activity during the three week study duration. Accelerometer data to be reported includes: daily number of steps, daily sitting time, daily stepping time, total sedentary time, and activity score.
- Oral Glucose Tolerance Test (OGTT)Days 0, 7, and 14
On the morning of each OGTT, participants will arrive in the lab following an 8-10 h fast. An indwelling intravenous catheter will be placed into a forearm vein. Baseline (0 min) blood samples will be collected into heparinized evacuated tubes following 15 min of seated rest. Participants will consume a volume of glucose tolerance beverage containing 1 gram of glucose/kg of lean body mass to control for expected differences in body and fat mass between individuals. Participants will remain rested in the reclined position for the duration of the OGTT. Blood samples will be collected at 30, 60, 90, and 120 min post drink. Heparinized blood samples will be utilized to assess blood glucose using the Contour Next blood glucose monitoring system.
- Continuous Glucose Monitoring3 weeks
Participants will wear CGM sensors for the duration of the study, with the first sensor being placed on day -7 and a second sensor replacing it on day 0. Data will be exported and quality-checked data will be imported into the IGlu Application in R Studio and analyzed using the following parameters: Night hours set from 10 PM to 7 AM; Time above (high) set to 140 mg/dL; Time above (low) set to 120 mg/dL; Time in range set to 70-120 mg/dL; Time below (high) set to 70 mg/dL; Time below (low) set to 54 mg/dL; Data reported using this software includes weekly and daily means, standard deviations (SD), coefficient of variations (CV), medians, time below range \< 54 mg/dL (TBR \<54), time below range \< 70 mg/dL (TBR \<70), time in range 70-120 mg/dL (TIR 70-120), time above range \>120 mg/dL (TAR \>120), time above range \>140 mg/dL (TAR \>140), mean amplitude of glycemic excursions (MAGE), and area under the curve (AUC).
- Femoral Artery Blood FlowDays 0, 7, and 14
Passive leg movement (PLM)-induced reactive hyperemia will be measured to assess peripheral vascular function. Briefly, the PLM technique involves passive movement of the leg to elicit a reactive hyperemic response measured by high-frequency ultrasonographic imaging. Diameter and blood velocity in the common femoral artery will be measured following 15 minutes of seated rest using a 5 to 12MHz multi-frequency linear array transducer connected to a high-resolution ultrasound. Arterial diameter and velocity will be recorded continuously for 60 seconds at baseline and 60 seconds during PLM. Femoral artery blood flow and shear rate (estimate of shear stress) will be calculated from arterial diameter and blood velocity measurements.