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Transcranial Magnetic Stimulation + Language Therapy for Mild Aphasia

This study is testing if Transcranial Magnetic Stimulation (TMS), a non-invasive brain stimulation using magnetic pulses, combined with Speech-Language Therapy (SLT) can help people with mild aphasia after a stroke. Aphasia is a language disorder that can happen after a stroke. Researchers want to see if this combination treatment can improve conversational speech and understanding. They will compare real TMS to a "sham" (fake) TMS to understand its effects. You might be able to join if you are 40 to 85 years old, had a stroke in the left side of your brain more than 6 months ago, have mild aphasia (a specific score on a language test), and are proficient in English. The study aims to enroll 24 participants.

Study design
This is an interventional study comparing real Transcranial Magnetic Stimulation (TMS) to sham TMS, combined with Speech-Language Therapy (SLT). It plans to enroll 24 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed to measure sentence processing from the start of the study up to 4 months after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06842745

Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia

Recruiting
PHASE2Ages 40–85InterventionalTreatment
University of Pennsylvania
~24 participants
Updated 2026-03-05 on ClinicalTrials.gov
What's tested:Transcranial Magnetic Stimulation (TMS)Speech-Language Therapy (SLT)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sentence Processing
Measured over From baseline to 4 months post-intervention

Conditions

Aphasia
Stroke
Aphasia Following Cerebral Infarction
Aphasia, Acquired

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Aphasia

NCT06842745

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Pennsylvania

    Philadelphia, Pennsylvaniano site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • H. Branch Coslett, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

Who to contact

Harris Drachman, MS
[email protected]
215-964-2502
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Left Hemisphere stroke
Stroke occurred more than 6 months ago
Mild Aphasia (WAB AQ score \> 85)
Proficient in English

Exclusion

Ongoing substance or alcohol abuse
Other neurological disorders, beside stroke (i.e. dementia, traumatic brain injury, multiple sclerosis)
Active psychiatric disorders (i.e. bipolar disorder, schizophrenia)
Pacemaker or cardiac defibrillator
Diagnosis of tinnitus
Epilepsy, or seizure in the past 6 months

What this trial measures

  • Sentence ProcessingFrom baseline to 4 months post-intervention

    Change in performance on the Temple Assessment of Language and Short-term Memory in Aphasia (TALSA) sentence processing composite score.