Observational Study on Bite Force and Dental Pain

This study is looking at how dental pain, specifically from conditions like irreversible pulpitis (inflammation of the tooth's nerve), apical periodontitis (inflammation around the tooth's root), and pulpal necrosis (death of the tooth's nerve), affects bite force. Researchers want to understand if certain pain mechanisms, like mechanical allodynia (pain from normally non-painful touch) and central sensitization (when your nervous system becomes over-sensitive to pain), play a role. The goal is to see if these mechanisms can be targets for new pain treatments, potentially reducing the need for opioids. You might be able to join if you are between 18 and 89 years old and are getting a filling or root canal on a lower molar tooth. The study aims to measure mechanical allodynia and central sensitization to understand how dental pain works. The current recruitment status is unclear.

Study design
This is an observational study planning to enroll 112 participants. It is not specified if it is randomized, blinded, or what phase it is.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study measures mechanical allodynia at baseline and 10 minutes after local anesthesia, and central sensitization at baseline.

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NCT06843525

Bite Force Measurements

Recruiting
Not specifiedAges 18–89Observational
Rutgers, The State University of New Jersey
~112 participants
Updated 2025-07-24 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mechanical Allodynia
Measured over Baseline
+3 more outcomes measured
Irreversible Pulpitis
Apical Periodontitis
Pulpal Necrosis
1 sites across 1 states
New Jersey1
  • Varvara Vanessa Chrepa, DDS, MS, PhD · PRINCIPAL_INVESTIGATOR · Rutgers School of Dental Medicine
  • Gayathri Subramanian, PhD, DMD · PRINCIPAL_INVESTIGATOR · Rutgers School of Dental Medicine

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Eligibility criteria

Inclusion

Individuals who present for
a lower 1st or 2nd molar filling in an otherwise healthy tooth, i.e., does not have large decay that has already infected the nerve of the tooth, or there is increased mobility due to gum disease or a root canal treatment on a lower molar tooth and there is no history of injury to the tooth, or
a lower molar root canal treatment, and
are 18 years or older
capable of providing informed consent, are eligible to participate in the study, as long as they satisfy the criteria below.
The opposing tooth is present, symptom-free and has adequate tooth structure that allows it to make contact with the tooth it bites against, and
are English-speaking

Exclusion

Any patient, even if satisfying the criteria above, may not take part if any of the below is true:
Compromised ability to guard their self-interest, for e.g., prisoners, children, pregnant women, patients with intellectual/cognitive disability are not enrolled in the study.
Take prescription pain medications for long-standing health conditions
Addiction/ substance dependence
Swelling that extends beyond the tooth in question
Are already taking an antibiotic to treat an infection/swelling
Missing complementary molar on the same or opposite side of the mouth
Missing more than 2 teeth in a quadrant (other than 3rd molars)
Any other molar in the pair either on the side of the tooth of interest or the molar pair on the other side is painful to biting pressure or upon 'tapping' the tooth with the handle of the mouth mirror
The patient has taken a pain medication within the last 6 hours
  • Mechanical AllodyniaBaseline

    Ipsilateral full arch and tooth specific bite-force

  • Mechanical Allodynia10 minutes post-local anesthesia

    Ipsilateral full arch and tooth specific bite-force

  • Central SensitizationBaseline

    Contralateral tooth specific bite-force

  • Central Sensitization10 minutes post-local anesthesia

    Contralateral tooth specific bite-force