Understanding Uterine Fluid Absorption in Early Pregnancy

This observational study, called the ELF Study, is looking into how the uterus absorbs fluid during early pregnancy. Researchers want to understand the mechanisms (how things work) involved. You might be able to join if you are a woman between 18 and 45 years old with regular periods and a BMI between 18 and 40. The study is open to women with diagnosed endometriosis (a condition where tissue similar to the lining of the uterus grows outside the uterus) or infertility, as well as women without these conditions. The main goal is to measure the levels of certain ion channels (tiny pathways that allow charged particles to pass through cell membranes) in uterine tissue samples over five years to see how they relate to fluid absorption. The current enrollment status is unclear, and the study plans to include 140 participants.

Study design
This is an observational study, meaning researchers will observe and collect information without providing any specific interventions. It plans to enroll 140 women.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint will be measured at 5 years, suggesting a long-term follow-up.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06847685

Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)

Recruiting
Not specifiedAges 18–45Observational
Johns Hopkins University
~140 participants
Updated 2026-03-09 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Expression levels of selected ion channels in human endometrium biopsies across the menstrual cycle.
Measured over 5 years
Endometriosis
Endometrioma
3 sites across 3 states
Georgia1
Maryland1
New Jersey1
  • James Segars, MD · STUDY_CHAIR · Johns Hopkins University
  • Bhuchitra Singh, MD, MPH, MS, MBA · STUDY_DIRECTOR · Johns Hopkins University

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  • Expression levels of selected ion channels in human endometrium biopsies across the menstrual cycle.5 years

    Immunolocalization of ion channel levels ENaCα, SLC5A1 and SLC5A3 in endometrial tissues.