Understanding Brain Activity in Movement Disorders

This study aims to better understand how certain brain areas (cortex, basal ganglia, thalamus, and cerebellum) are involved in movement disorders like Parkinson's disease, dystonia, and essential tremor. Researchers will record brain electrical activity using non-invasive scalp electrodes or through deep brain stimulation (DBS) devices if you have one that can sense brain activity. These recordings, along with your movement disorder symptoms, will help identify specific brain signals related to these conditions. You might be eligible if you are 18 or older and have a diagnosed movement disorder, but not dementia. The study plans to enroll 100 participants and is ongoing, with brain signal biomarkers measured over 5 years.

Study design
This is an interventional study with a planned enrollment of 100 participants. It is not specified if the study is randomized or blinded.
What's involved
Recordings will be made from your scalp with a noninvasive electrode, or through your DBS stimulator if you have one. Your prescribed medications and DBS settings may be adjusted within normal clinical limits.
Compensation
Not stated in the trial record.
Follow-up
Neural signal biomarkers will be measured at 5 years.

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NCT06848530

Neurophysiology of the Basal Ganglia, Thalamus, and Cerebellum in Patients With Movement Disorders

Recruiting
NAAges 18+InterventionalBasic science
University of Pennsylvania
~100 participants
Updated 2026-07-14 on ClinicalTrials.gov
What's tested:Prescribed MedicationsDeep brain stimulation adjustment

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Neural signal biomarkers
Measured over 5 years
Movement Disorders
1 sites across 1 states
Pennsylvania1

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Eligibility criteria

Inclusion

Patients 18 years of age and above
Any patient who has been diagnosed by a movement disorders neurologist with one of the following movement disorders:
Parkinson's disease
Dystonia
Tremor, including essential tremor
Cerebellar ataxia
Other hyperkinetic movement disorders, such as chorea and tics
  • Neural signal biomarkers5 years

    Spatiotemporal patterns of brain neural activity (neural signal biomarkers / neurophysiologic signatures) associated with movement disorders symptoms.