H5N1 Milk Detection Study

This study is looking at whether drinking pasteurized milk that contains inactive (killed) particles of the A(H5) flu virus could lead to the virus being detected in your nose or throat. These inactive virus particles cannot make you sick. Researchers want to see if this happens and if your body makes antibodies in response. The results will help the Centers for Disease Control and Prevention (CDC) understand how milk consumption might affect flu monitoring. You could be eligible if you are a healthy adult between 18 and 64 years old, have a BMI of 35 or less, and can understand and agree to the study procedures. The study aims to enroll 30 participants.

Study design
This is an interventional study planning to enroll 30 participants. It is not specified if it is randomized or blinded.
What's involved
You would drink 250 mL of pasteurized milk containing inactive H5N1 virus, either once or over three days. Nasal and throat swabs will be taken, and some participants will also provide blood, saliva, and stool samples.
Compensation
Not stated in the trial record.
Follow-up
Your respiratory specimens will be checked for influenza for up to 30 days after drinking the milk. Some participants will provide samples again 21-30 days post-consumption.

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NCT06850298

H5N1 Milk Detection Study

Recruiting
NAAges 18–64InterventionalBasic science
Emory University
~30 participants
Updated 2026-04-15 on ClinicalTrials.gov
What's tested:Pasteurized milk contaminated with killed A(H5) virus

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of respiratory specimens with influenza detected
Measured over Up to 30 days after milk consumption
Influenza
1 sites across 1 states
Georgia1
  • Daniel Graciaa, MD, MPH, MSc · PRINCIPAL_INVESTIGATOR · Emory University

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Eligibility criteria

Inclusion

Individuals aged 18-64 years
BMI ≤ 35 kg/m2
Able to understand and give informed consent (American English) and comply with study visits and procedures.
In good general health based on medical history and the investigator's clinical judgment.

Exclusion

Symptoms of acute respiratory illness or conjunctivitis within 7 days
Febrile illness in the previous 72 hours
Recent influenza antiviral use (within 14 days)
Immunosuppression due to illness or medications
Current pregnancy or breastfeeding
History of allergy or intolerance to milk or milk alternatives
Consumption of raw (unpasteurized) milk within the previous 14 days
Recent work (within 14 days) on a farm with animals known to be infected with A(H5) virus
Previous receipt of A(H5) vaccine at any time
  • Proportion of respiratory specimens with influenza detectedUp to 30 days after milk consumption

    Proportion of respiratory specimens (nasopharyngeal and combined nasal/oropharyngeal swabs) with detection of influenza after consumption of pasteurized milk contaminated with killed A(H5) virus