This study is looking at how Lorazepam, an FDA-approved anxiety medication, affects brain activity in Veterans with Post-Traumatic Stress Disorder (PTSD). Many Veterans with PTSD still struggle even with current treatments, and this research aims to find better ways to match individuals with the right medications. Researchers believe that a specific group of Veterans with high anxiety might benefit from medications that boost a brain chemical called GABA. This study will compare the effects of a single dose of Lorazepam to a placebo (an inactive pill that looks and tastes the same). The main goal is to see how these medications affect your ability to control your movements and reactions, measured about 1.5 hours after taking the pill. You might be able to join if you are a Veteran between 18 and 65 years old and willing to avoid alcohol before and after the study session. The study plans to enroll 150 participants, but its current status is unclear.

Study design

This interventional study plans to enroll 150 participants and compares Lorazepam to a placebo.

What's involved

You would need to abstain from alcohol 24 hours before and 24 hours after the testing session.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint is measured 1.5 hours after dosing, but no longer-term follow-up is specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.