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Hyperpolarized Xenon-129 MRI for Idiopathic Pulmonary Fibrosis

This study is looking at a new way to image the lungs of people with Idiopathic Pulmonary Fibrosis (IPF), a serious lung disease. Researchers are using a special type of MRI called Hyperpolarized Xe129-MRI to see if it can detect problems with how blood flows through the lungs. They believe this imaging technique could help understand the disease better and track how it changes over time. You might be able to join if you are 18 or older, have a clinical diagnosis of IPF, and meet other health requirements. The main goal is to measure how well this MRI technique works in people with IPF. The study is currently unclear on its recruitment status and plans to enroll 6 participants.

Study design
This is an interventional study with an unclear phase, planning to enroll 6 participants.
What's involved
You would undergo a Hyperpolarized Xe129-MRI procedure at the University of Virginia, which takes about 3 hours.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured up to 24 hours after the MRI imaging.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06853145

Hyperpolarized Xenon-129 MRI in Idiopathic Pulmonary Fibrosis

Recruiting
EARLY_PHASE1Ages 18+InterventionalBasic science
University of Virginia
~6 participants
Updated 2025-07-09 on ClinicalTrials.gov
What's tested:Hyperpolarized Xe129

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Measuring the ventilation effect of HXe129 MRI for IPF subjects
Measured over Up to 24 hours post MR Imaging

Conditions

Idiopathic Pulmonary Fibrosis

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Idiopathic Pulmonary Fibrosis

NCT06853145

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Snyder Building 480 Ray C. Hunt Drive

    Charlottesville, Virginiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • John Kim, MD · PRINCIPAL_INVESTIGATOR · University of Virginia

Who to contact

Roselove Asare, MA
[email protected]
4342436074
Email the study team

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Eligibility criteria

Inclusion

Able to provide informed consent 18 years of age or greater Clinical diagnosis of IPF

Exclusion

Continuous oxygen use at home
Oxygen saturation less than 92% on the day of MRI procedure
Pregnancy or lactation
Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning. Subjects with any implanted device that cannot be verified as MRI compliant will be excluded.
History of congenital cardiac disease, chronic renal failure, or cirrhosis. • Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches.
Inability to understand simple instructions or to hold still for approximately 10-15 seconds.
History of respiratory infection within 2 weeks prior to the MR scan
History of MI, stroke and/or poorly controlled hypertension.

What this trial measures

  • Measuring the ventilation effect of HXe129 MRI for IPF subjectsUp to 24 hours post MR Imaging

    We will initially use descriptive statistics to describe the hyperpolarized Xe129 MRI indices and visualize their distribution using histograms. Paired t-test will be used to examine differences between baseline and follow-up hyperpolarized Xe129 MRI indices. Given that SA2 is to prove feasibility of accomplishing the MRI procedure, we have purposely opted to not adjust for the multiple MRI measurements that will be obtained.