Stress Cardiac MRI for Ischemic Heart Disease
This study is looking at how well a special type of heart MRI can diagnose heart problems in people with chest pain or abnormal EKGs (electrocardiograms). The researchers want to see if detailed measurements of blood flow to the heart muscle, using a diagnostic test called Quantitative Myocardial Blood Flow Evaluation along with Gadavist (a contrast dye) and a Vasodilator (a medicine to widen blood vessels), can better identify blockages or inflammation compared to standard MRI pictures. They will also collect a blood sample for laboratory assessment. The goal is to see if these detailed measurements can help doctors understand the severity of heart disease more accurately. The study plans to enroll 1000 participants aged 35 to 85 years old. The study's success will be measured by how well it predicts major heart-related problems over 24 months. The current recruitment status is unclear.
- Study design
- This is an interventional study planning to enroll 1000 participants. It compares different ways of evaluating blood flow to the heart using MRI.
- What's involved
- You would undergo a stress cardiac magnetic resonance imaging (MRI) procedure, which involves receiving Gadavist and a Vasodilator. A single blood sample would also be collected.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for 24 months after their cardiac magnetic resonance imaging.
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The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study
At a glance
Conditions
Where it's being run
12 sites across 9 statesWho to contact
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What this trial measures
- Primary composite outcome of major cardiovascular adverse events (MACE)From cardiac magnetic resonance imaging to the end of follow-up in 24 months
Composite MACE includes cardiovascular death, non-fatal acute myocardial infarction, stroke, resuscitated cardiac arrest, unnecessary invasive coronary angiography, and any cardiac hospitalization. Unnecessary invasive coronary angiography is defined as any invasive coronary angiography performed within 6 months after study enrollment, which reviews no obstructive coronary disease and no revascularization performed.