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Fluid Balance Study with Electrolyte and Glycerol Beverages

This study is looking at how different drinks affect your body's fluid balance. Researchers want to see if adding ingredients like sodium and glycerol to beverages, and changing the amount you drink, helps your body hold onto fluids better instead of losing them through urination. You would drink different flavored beverages, including a placebo (a drink with no active ingredients), electrolyte solutions without glycerol, and electrolyte solutions with glycerol. The main goal is to measure your fluid balance after drinking these beverages over several hours. This study is for healthy men and women between 18 and 50 years old who are physically active.

Study design
This is an interventional study with a planned enrollment of 80 healthy men and women. It compares several different beverage types and volumes.
What's involved
You would drink beverages over a 35-minute period, followed by a 25-minute rest. Your fluid balance will be measured at various times for up to 210 minutes (3.5 hours) after drinking.
Compensation
Not stated in the trial record.
Follow-up
Your fluid balance will be measured for up to 210 minutes (3.5 hours) after you drink the beverages.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06854471

Effects of Beverage Volume, Glycerol Concentration, and Sodium Concentration on Fluid Balance in Healthy Euhydrated Men and Women at Rest

Recruiting
NAAges 18–50Interventional
PepsiCo Global R&D
~80 participants
Updated 2025-07-17 on ClinicalTrials.gov
What's tested:Placebo beverage, kiwi-strawberry flavorElectrolyte solution without glycerol beverage 1Electrolyte solution without glycerol beverage 2Electrolyte solution without glycerol beverage 3Electrolyte solution with glycerol beverage 1Electrolyte solution with glycerol beverage 2

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Fluid balance
Measured over Change from baseline (pre-beverage) to post-beverage Time 30, 60, 90,120, 150,180 and 210 minutes

Conditions

Fluid Balance

Explore related trials

Healthy

Where it's being run

3 sites across 2 states
Florida2
New York1

Study leadership

  • Lindsay Baker, PhD · PRINCIPAL_INVESTIGATOR · PepsiCo R&D/Gatorade and Sports Science Institute

Who to contact

Lindsay Baker, PhD
[email protected]
800.884.2867
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Subject is male or female
If female, subject is not pregnant
Subject is 18-50 years of age, inclusive
Subject is at least recreationally active (engaged in light to moderate-intensity, intermittent, or steady-state exercise at least 3 days per week for at least 30 min at a time)
Subject does not smoke (or has quit for at least 6 months)
Subject is not taking medication that may interfere with the study (e.g., diuretics)
Subject has no health conditions that would interfere with the study (e.g. cardiovascular, renal, or metabolic diseases)
Subject is willing to avoid alcohol consumption 24 hours prior to visit(s)
Subject is willing to fast overnight (\~8-12 hours)
Subject is willing to refrain from vigorous exercise for 24 hours
Subject is willing to eat the exact same food the day prior to each visit to the laboratory
Provision of written consent to participate

Exclusion

Subject has participated in a clinical trial within the past 30 days
Subject has participated in any PepsiCo trial within past 6 months
Subject has a condition or is taking medication that the investigator believes would interfere with his/her ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the person at undue risk
Subject is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If subject is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.

What this trial measures

  • Fluid balanceChange from baseline (pre-beverage) to post-beverage Time 30, 60, 90,120, 150,180 and 210 minutes

    Calculated as change in body mass kg and %