This study is looking at how well hormone therapy helps women living with HIV who are experiencing hot flashes and night sweats (vasomotor symptoms) during menopause. Women living with HIV often have more severe hot flashes, which can affect sleep, mood, and daily life. While hormone therapy is known to help women without HIV, its effects haven't been fully studied in women with HIV. This trial will test transdermal estradiol gel and, for those with an intact uterus, micronized progesterone, against placebo (an inactive substance) for 12 weeks. The main goal is to see if these treatments reduce the frequency of hot flashes and night sweats. You can join if you are a woman with HIV, aged 40-60, in menopause, and experiencing these symptoms. The current status of this study is unclear.

Study design

This interventional study plans to enroll 105 women. Participants will receive either active hormone therapy (transdermal estradiol gel and possibly micronized progesterone) or a placebo for 12 weeks.

What's involved

You would apply a gel to your skin daily for 12 weeks and, if applicable, take a pill daily for 12 weeks. You would also need to complete a daily diary.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint measures changes in symptoms up to Week 12, which is the end of the treatment period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.