Feasibility of Resting Intervals During Exercise Programs for Knee Osteoarthritis

This study is looking at how practical it is to offer two different exercise programs to people with knee osteoarthritis (a condition where the cartilage in your knee joint wears down). You could be eligible if you are between 45 and 79 years old, have a clinical diagnosis of primary, early to moderate stage knee osteoarthritis, and a body mass index (BMI) under 35 kg/m2. The study aims to see how easy it is to recruit participants. There are two groups: one does an exercise program with two 45-minute rest periods, and the other does the same exercise program with minimal rest. Both groups exercise three times a week for 12 weeks. The study is currently unclear on its recruitment status and plans to enroll 20 participants.

Study design
This is a pilot randomized trial where participants are randomly assigned to one of two exercise groups. It plans to enroll 20 participants.
What's involved
You would exercise three times a week for 12 weeks. Before and after the exercise programs, you would have assessments including gait analysis, MRI scans of your knees, muscle strength tests, physical performance tests, questionnaires, and blood and synovial fluid collection.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06857123

Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis

Recruiting
NAAges 45–79InterventionalTreatment
University of Pittsburgh
~20 participants
Updated 2026-02-09 on ClinicalTrials.gov
What's tested:Exercise with RestExercise without Rest

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of recruitment
Measured over The time frame for this outcome is from the enrollment period up to randomization. This outcome measure is independent of treatment assignment.
Knee Osteoarthristis

NCT06857123

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Pittsburgh

    Pittsburgh, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Sara Piva · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

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Eligibility criteria

Inclusion

Age between 45 and 79 yo.
Clinical diagnosis of primary, early to moderate stage knee osteoarthritis.
BMI range \< 35 kg/m2.
Sedentary lifestyle
Knee joint is the most painful joint in the body.
Ability to speak and understand English.
Willingness to comply with all study procedures and be available for the duration of the study.

Exclusion

Non-OA disease of the knee.
Advanced knee osteoarthritis
Knee injection in the past 3 months.
Major knee trauma/surgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment..
Participate in regular exercise or physical activity .
Participation in an intervention study for knee OA.
Currently using a cane, walker or crutches to walk.
History of cardiovascular disease or hypertension not controlled by medication.
Two or more unexplained falls in the past year.
Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise.
Contraindication to MRI.
Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s/he from complying with study procedures.
Pregnant female.
Acute or terminal illness.
  • Feasibility of recruitmentThe time frame for this outcome is from the enrollment period up to randomization. This outcome measure is independent of treatment assignment.

    The number of eligible individuals who are randomized out of all eligible individuals.