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Autologous Fat Grafting for Scar Contracture

This study is looking at a new way to treat scars from burns or injuries using your own body fat. Researchers want to see if a procedure called "Autologous Layered Composite Grafting" (where fat is taken from your body and placed directly into the wound) works as well as, or better than, traditional "Full Thickness Skin Grafts" (where a piece of skin is moved from one part of your body to another). The goal is to improve healing, reduce scarring, and lower the risk of infection. You might be able to join if you are 18 or older, have scar contracture from a burn or injury, and are willing to be randomly assigned to receive a fat graft. The study will measure changes in scar size from the time of surgery up to 9 months later.

Study design
This is an interventional study comparing two surgical procedures for scar reconstruction. It plans to enroll 40 adult participants.
What's involved
You will receive fat grafting at the time of your scar revision surgery. The study will monitor your scar healing for 9 months after surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed from the time of surgery up to 9 months for changes in scar surface area.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06857435

Autologous Point-of-Care Adipose Therapy: Delayed Injury/Scar

Recruiting
NAAges 18+InterventionalTreatment
University of Pittsburgh
~40 participants
Updated 2026-07-22 on ClinicalTrials.gov
What's tested:Full Thickness Skin Graft (FTSG)Base of wound fat graft with Split Thickness Skin Graft (STSG) Reconstruction (Autologous Layered Composite Grafting).

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in scar contracture, as measured by change in scar surface area size
Measured over From surgery to 9-month clinical endpoint.

Conditions

Burns
Contracture Scar
Surgical Injury

Explore related trials

BurnContracture scarInjuries, Surgical

Where it's being run

2 sites across 1 states
Pennsylvania2

Study leadership

  • Francesco Egro · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Eleanor Shirley
[email protected]
412-641-8676
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

The proposed study will include adult patients 18 years of age or older,
male or female,
civilian, military, active duty or retired veterans
presenting for scar contracture release and reconstruction at any level.

Exclusion

Age \< 18 years of age,
active infection,
medical co-morbidities or anatomic configuration deemed by the physician to be a concern for safety,
unwilling or unable to comply with study procedures,
radiation to the site of interest,
prisoners and/or vulnerable populations.
In addition, candidates that are pregnant or plan to become pregnant in the next year, will be excluded.

What this trial measures

  • Change in scar contracture, as measured by change in scar surface area sizeFrom surgery to 9-month clinical endpoint.

    Contracture as measured by change in surface area of reconstruction between time of surgery and 9-month clinical endpoint/maturation of reconstruction. These data will be derived by serial photography.